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Literature summary extracted from

  • Low, M.G.; Weglicki, W.B.
    Resolution of myocardial phospholipase C into several forms with distinct properties (1983), Biochem. J., 215, 325-334.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.11 deoxycholate stimulates activity of enzyme I, II and III at pH 7 Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.11 EGTA
-
 Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.11 Ca2+ enzyme requires 2-5 mM CaCI2 for maximal activity Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.11 40000 43000 enzyme form II, gel filtration Bos taurus
3.1.4.11 58000 76000 enzyme form III, gel filtration Bos taurus
3.1.4.11 105000 120000 enzyme form I, gel filtration Bos taurus
3.1.4.11 256000 271000 enzyme form IV, gel filtration Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.11 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.11 heart
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.11 additional information phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine are no substrates Bos taurus ?
-
 ?
3.1.4.11 phosphatidylinositol + H2O
-
 Bos taurus ?
-
 ?
3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O
-
 Bos taurus ?
-
 ?
3.1.4.11 phosphatidylinositol 4-phosphate + H2O
-
 Bos taurus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.11 myocardial phospholipase C type I, II, III, and IV Bos taurus
3.1.4.11 phospholipase C type I, II, III, and IV Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.11 37
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.11 4.5 5.5 type I, II, and III. The major form (III) also has substantial activity at pH 7.0 and above 4 Bos taurus