BRENDA - Enzyme Database

Phosphomannose isomerase from Saccharomyces cerevisiae contains two inhibitory metal ion binding sites

Wells, T.N.C.; Coulin, F.; Payton, M.A.; Proudfoot, A.E.I.; Biochemistry 32, 1294-1301 (1993)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.1.8
Cd2+
competitive, strongly pH dependent
Saccharomyces cerevisiae
5.3.1.8
Hg2+
competitive, relatively pH-independent. Zn2+ and Hg2+ can simultaneously bind in the mannose 6-phosphate binding pocket, with only a small mutual repulsion
Saccharomyces cerevisiae
5.3.1.8
Zn2+
competitive with mannose 6-phosphate, strongly pH-dependent. Zn2+ and Hg2+ can simultaneously bind in the mannose 6-phosphate binding pocket, with only a small mutual repulsion
Saccharomyces cerevisiae
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.1.8
Saccharomyces cerevisiae
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.1.8
D-Mannose 6-phosphate
-
2816
Saccharomyces cerevisiae
D-Fructose 6-phosphate
-
2816
Saccharomyces cerevisiae
-
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.1.8
Cd2+
competitive, strongly pH dependent
Saccharomyces cerevisiae
5.3.1.8
Hg2+
competitive, relatively pH-independent. Zn2+ and Hg2+ can simultaneously bind in the mannose 6-phosphate binding pocket, with only a small mutual repulsion
Saccharomyces cerevisiae
5.3.1.8
Zn2+
competitive with mannose 6-phosphate, strongly pH-dependent. Zn2+ and Hg2+ can simultaneously bind in the mannose 6-phosphate binding pocket, with only a small mutual repulsion
Saccharomyces cerevisiae
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.1.8
D-Mannose 6-phosphate
-
2816
Saccharomyces cerevisiae
D-Fructose 6-phosphate
-
2816
Saccharomyces cerevisiae
-