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Literature summary extracted from
- Catabolism of 3-hydroxybenzoate by the gentisate pathway in Klebsiella pneumoniae M5a1 (1990), Arch. Microbiol., 154, 489-495.
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.2.1.4 | 3-Maleylpyruvate | Klebsiella pneumoniae | enzyme of the gentisate pathway | ? | - |
? |  |
| 5.2.1.4 | 3-Maleylpyruvate | Klebsiella pneumoniae | mutants lacking maleylpyruvate isomerase accumulate maleylpyruvate when exposed to 3-hydroxybenzoate and growth is inhibited | ? | - |
? | |
| 5.2.1.4 | 3-Maleylpyruvate | Klebsiella pneumoniae M5al | enzyme of the gentisate pathway | ? | - |
? | |
| 5.2.1.4 | 3-Maleylpyruvate | Klebsiella pneumoniae M5al | mutants lacking maleylpyruvate isomerase accumulate maleylpyruvate when exposed to 3-hydroxybenzoate and growth is inhibited | ? | - |
? | |
| 5.2.1.4 | 3-Maleylpyruvate | Klebsiella pneumoniae M5a1 | enzyme of the gentisate pathway | ? | - |
? | |
| 5.2.1.4 | 3-Maleylpyruvate | Klebsiella pneumoniae M5a1 | mutants lacking maleylpyruvate isomerase accumulate maleylpyruvate when exposed to 3-hydroxybenzoate and growth is inhibited | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.13.11.4 | Klebsiella pneumoniae | - |
- |
- |
| 3.7.1.5 | Klebsiella pneumoniae | - |
activity occurs also in strains OH101, MI214, and MI214/1 | - |
| 3.7.1.5 | Klebsiella pneumoniae M5al | - |
activity occurs also in strains OH101, MI214, and MI214/1 | - |
| 5.2.1.4 | Klebsiella pneumoniae | - |
- |
- |
| 5.2.1.4 | Klebsiella pneumoniae M5a1 | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.7.1.5 | additional information | strain M5al grows well on 3-hydroxybenzoate, 2,5-dihydroxybenzoate (gentisate), and 3,4-dihydroxybenzoate (protocatechuate), but does not grow on 4-hydroxybenzoate. Growth on 3-hydroxybenzoate and 2,5-dihydroxybenzoate leads to the induction of 3-hydroxybenzoate monooxygenase, 2,5-dihydroxybenzoate dioxygenase, maleylpyruvate isomerase and fumarylpyruvate hydrolase | Klebsiella pneumoniae | - |
| 5.2.1.4 | culture condition:2,5-dihydroxybenzoate-grown cell | - |
Klebsiella pneumoniae | - |
| 5.2.1.4 | culture condition:3-hydroxybenzoate-grown cell | - |
Klebsiella pneumoniae | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.13.11.4 | 1040 | - |
- |
Klebsiella pneumoniae |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.11.4 | 2,5-dihydroxybenzoate + O2 | - |
Klebsiella pneumoniae | maleylpyruvate | - |
? | |
| 1.13.11.4 | 2,5-dihydroxybenzoate + O2 | - |
Klebsiella pneumoniae M5al | maleylpyruvate | - |
? | |
| 1.13.11.4 | 2,5-dihydroxybenzoate + O2 | - |
Klebsiella pneumoniae M5a1 | maleylpyruvate | - |
? | |
| 3.7.1.5 | 3-fumarylpyruvate + H2O | - |
Klebsiella pneumoniae | fumarate + pyruvate | - |
? | |
| 3.7.1.5 | 3-fumarylpyruvate + H2O | - |
Klebsiella pneumoniae M5al | fumarate + pyruvate | - |
? | |
| 3.7.1.5 | 3-fumarylpyruvate + H2O | - |
Klebsiella pneumoniae M5a1 | fumarate + pyruvate | - |
? | |
| 5.2.1.4 | 3-Maleylpyruvate | enzyme of the gentisate pathway | Klebsiella pneumoniae | ? | - |
? | |
| 5.2.1.4 | 3-Maleylpyruvate | mutants lacking maleylpyruvate isomerase accumulate maleylpyruvate when exposed to 3-hydroxybenzoate and growth is inhibited | Klebsiella pneumoniae | ? | - |
? | |
| 5.2.1.4 | 3-Maleylpyruvate | enzyme of the gentisate pathway | Klebsiella pneumoniae M5al | ? | - |
? | |
| 5.2.1.4 | 3-Maleylpyruvate | mutants lacking maleylpyruvate isomerase accumulate maleylpyruvate when exposed to 3-hydroxybenzoate and growth is inhibited | Klebsiella pneumoniae M5al | ? | - |
? | |
| 5.2.1.4 | 3-Maleylpyruvate | enzyme of the gentisate pathway | Klebsiella pneumoniae M5a1 | ? | - |
? | |
| 5.2.1.4 | 3-Maleylpyruvate | mutants lacking maleylpyruvate isomerase accumulate maleylpyruvate when exposed to 3-hydroxybenzoate and growth is inhibited | Klebsiella pneumoniae M5a1 | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.7.1.5 | fumarylpyruvate hydrolase | - |
Klebsiella pneumoniae |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.7.1.5 | 37 | - |
assay at | Klebsiella pneumoniae |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.7.1.5 | 7.1 | - |
assay at | Klebsiella pneumoniae |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 3.7.1.5 | Klebsiella pneumoniae | growth on 3-hydroxybenzoate and 2,5-dihydroxybenzoate leads to the induction of fumarylpyruvate hydrolase | up |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.7.1.5 | metabolism | the enzyme catalyzes the last step in the gentisate pathway for 3-hydroxybenzoate catabolism | Klebsiella pneumoniae |
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