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Literature summary extracted from

  • Hoshino, M.
    Interactions of Tetrahymena dyneins with microtubule protein. Tubulin-induced stimulation of dynein ATPase activity (1976), Biochim. Biophys. Acta, 462, 49-62.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.6.1.2 tubulin from porcine brain, 3fold increase of 30S dynein activity at pH 10, maximum at a tubulin/30S dynein molar ratio of 10 Tetrahymena pyriformis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.6.1.2 0.01
-
 ATP 30S dynein, in the absence of tubulin, 1 mM KCl Tetrahymena pyriformis
5.6.1.2 0.23
-
 ATP 30S dynein, in the presence of tubulin, 1 mM KCl Tetrahymena pyriformis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.1.2 ATP + H2O + a dynein associated with a microtubule at position n Tetrahymena pyriformis
-
 ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.2 Tetrahymena pyriformis
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.6.1.2 2.5
-
 30S dynein, in the presence of tubulin Tetrahymena pyriformis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.2 ADP + H2O + a dynein associated with a microtubule at position n
-
 Tetrahymena pyriformis AMP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?
5.6.1.2 ATP + H2O + a dynein associated with a microtubule at position n
-
 Tetrahymena pyriformis ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?
5.6.1.2 CTP + H2O + a dynein associated with a microtubule at position n
-
 Tetrahymena pyriformis CDP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?
5.6.1.2 GTP + H2O + a dynein associated with a microtubule at position n
-
 Tetrahymena pyriformis GDP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?
5.6.1.2 ITP + H2O + a dynein associated with a microtubule at position n
-
 Tetrahymena pyriformis IDP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?
5.6.1.2 UTP + H2O + a dynein associated with a microtubule at position n
-
 Tetrahymena pyriformis UDP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?