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Literature summary extracted from

  • Peluffo, R.D.; Arguello, J.M.; Berlin, J.R.
    The role of Na,K-ATPase alpha subunit serine 775 and glutamate 779 in determining the extracellular K+ and membrane potential-dependent properties of the Na,K-pump (2000), J. Gen. Physiol., 116, 47-59.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.2.2.13 expressed in HeLa cells Ovis aries

Protein Variants

EC Number Protein Variants Comment Organism
7.2.2.13 E779A 15fold increase in K+ concentration that half-maximally activates Na,K-pump current at 0 mV in extracellular Na+-free solutions Ovis aries
7.2.2.13 N122D membrane potential and K+ dependence similar to wild-type Na,K-ATPase Ovis aries
7.2.2.13 Q111R membrane potential and K+ dependence similar to wild-type Na,K-ATPase Ovis aries
7.2.2.13 S775A 155fold increase in K+ concentration that half-maximally activates Na,K-pump current at 0 mV in extracellular Na+-free solutions Ovis aries

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.13 Ovis aries
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.13 ATP + H2O + Na+/in + K+/out
-
 Ovis aries ADP + phosphate + Na+/out + K+/in
-
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