EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
7.5.2.1 | G137A | mutation in MalK, fails to restore a functional transport complex in vivo, mutation increases the repressing activity of MalK on other maltose-regulated genes, loss of ability to hydrolyze ATP, but still displays nucleotide-binding activity | Salmonella enterica subsp. enterica serovar Typhimurium |
7.5.2.1 | G137T | mutation in MalK, fails to restore a functional transport complex in vivo, mutation increases the repressing activity of MalK on other maltose-regulated genes, loss of ability to hydrolyze ATP, but still displays nucleotide-binding activity | Salmonella enterica subsp. enterica serovar Typhimurium |
7.5.2.1 | G137V | mutation in MalK, fails to restore a functional transport complex in vivo, mutation increases the repressing activity of MalK on other maltose-regulated genes, loss of ability to hydrolyze ATP, but still displays nucleotide-binding activity | Salmonella enterica subsp. enterica serovar Typhimurium |
7.5.2.1 | Q140K | mutation in MalK, fails to restore a functional transport complex in vivo, mutation increases the repressing activity of MalK on other maltose-regulated genes, ATPase activity and MgATP-induced changes in tryptic cleavage pattern similar to those of wild-type. Mutant transport complexes containing MalKQ140K variant, when studied in proteoliposomes, are severely impaired in MalE-maltose-stimulated ATPase activity | Salmonella enterica subsp. enterica serovar Typhimurium |
7.5.2.1 | Q140L | mutation in MalK, fails to restore a functional transport complex in vivo, mutation increases the repressing activity of MalK on other maltose-regulated genes, fails to hydrolyze ATP and exhibits a strong intrinsic resistance to trypsin in the absence of MgATP, suggesting a drastically altered conformation | Salmonella enterica subsp. enterica serovar Typhimurium |
7.5.2.1 | Q140N | mutation in MalK, fails to restore a functional transport complex in vivo, mutation increases the repressing activity of MalK on other maltose-regulated genes, ATPase activity and MgATP-induced changes in tryptic cleavage pattern similar to those of wild-type. Mutant transport complexes containing MalKQ140N variant, when studied in proteoliposomes, are severely impaired in MalE-maltose-stimulated ATPase activity | Salmonella enterica subsp. enterica serovar Typhimurium |
EC Number | General Stability | Organism |
---|---|---|
7.5.2.1 | MgATP2-, binding protects against trypsin inactivation in wild-type enzyme in in G137 mutants | Salmonella enterica subsp. enterica serovar Typhimurium |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
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EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
7.5.2.1 | Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.5.2.1 | ATP + H2O + maltose/out | - |
Salmonella enterica subsp. enterica serovar Typhimurium | ADP + phosphate + maltose/in | - |
? |