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Literature summary extracted from

  • Chatterjee, P.K.; Das, P.K.
    Characterization of Syrian hamster gastric mucosal H+,K+-ATPase (1995), Mol. Cell. Biochem., 148, 95-103.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.19 amiloride
-
 Mesocricetus auratus
7.2.2.19 Ca2+ 2 mM, complete inhibition Mesocricetus auratus
7.2.2.19 F-
-
 Mesocricetus auratus
7.2.2.19 Mn2+ in presence of Mg2+ Mesocricetus auratus
7.2.2.19 N,N'-dicyclohexylcarbodiimide
-
 Mesocricetus auratus
7.2.2.19 Na+ above 100 mM, 60-70% inhibition Mesocricetus auratus
7.2.2.19 Nbd-Cl
-
 Mesocricetus auratus
7.2.2.19 oligomycin
-
 Mesocricetus auratus
7.2.2.19 Omeprazole
-
 Mesocricetus auratus
7.2.2.19 SCH28080
-
 Mesocricetus auratus
7.2.2.19 vanadate
-
 Mesocricetus auratus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.2.2.19 0.34
-
 K+
-
 Mesocricetus auratus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.19 membrane
-
 Mesocricetus auratus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.2.2.19 Cs+ activates, Km: 1.25 mM, monovalent cations stimulate in the order of decreasing efficacy: Tl+, K+, Rb+, NH4+, Cs+ Mesocricetus auratus
7.2.2.19 K+ maximum activation at 5-10 mM, Km: 0.34 mM, monovalent cations stimulate in the order of decreasing efficacy: Tl+, K+, Rb+, NH4+, Cs+ Mesocricetus auratus
7.2.2.19 Mg2+ activates Mesocricetus auratus
7.2.2.19 Mn2+ 77% of the activation with Mg2+, in absence of Mg2+ Mesocricetus auratus
7.2.2.19 NH4+ activates, Km: 3.64 mM, monovalent cations stimulate in the order of decreasing efficacy: Tl+, K+, Rb+, NH4+, Cs+ Mesocricetus auratus
7.2.2.19 Rb+ activates, Km: 0.43 mM, monovalent cations stimulate in the order of decreasing efficacy: Tl+, K+, Rb+, NH4+, Cs+ Mesocricetus auratus
7.2.2.19 Tl+ activates, Km: 0.03 mM, monovalent cations stimulate in the order of decreasing efficacy: Tl+, K+, Rb+, NH4+, Cs+ Mesocricetus auratus

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.19 Mesocricetus auratus
-
 i.e. Syrian hamster
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.19 stomach gastric mucosa Mesocricetus auratus
-

Storage Stability

EC Number Storage Stability Organism
7.2.2.19 -80°C, in glycerol containing buffer, stable for more than 6 months Mesocricetus auratus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.19 2'-deoxyATP + H2O + H+/in + K+/out 70% of the activity with ATP Mesocricetus auratus 2'-deoxyADP + phosphate + H+/out + K+/in
-
 ?
7.2.2.19 ADP + H2O + H+/in + K+/out 14% of the activity with ATP Mesocricetus auratus AMP + phosphate + H+/out + K+/in
-
 ?
7.2.2.19 ATP + H2O + H+/in + K+/out
-
 Mesocricetus auratus ADP + phosphate + H+/out + K+/in
-
 ?
7.2.2.19 CTP + H2O + H+/in + K+/out 20% of the activity with ATP Mesocricetus auratus CDP + phosphate + H+/out + K+/in
-
 ?
7.2.2.19 GTP + H2O + H+/in + K+/out 6% of the activity with ATP Mesocricetus auratus GDP + phosphate + H+/out + K+/in
-
 ?
7.2.2.19 ITP + H2O + H+/in + K+/out 5% of the activity with ATP Mesocricetus auratus IDP + phosphate + H+/out + K+/in
-
 ?
7.2.2.19 UTP + H2O + H+/in + K+/out 40% of the activity with ATP Mesocricetus auratus UDP + phosphate + H+/out + K+/in
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2.2.19 6.8
-
-
 Mesocricetus auratus