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Literature summary extracted from

  • Fernandez-Canon, J.M.; Penalva, M.A.
    Characterization of a fungal maleylacetoacetate isomerase gene and identification of its human homologue (1998), J. Biol. Chem., 273, 329-337.
    View publication on PubMed

Application

EC Number Application Comment Organism
5.2.1.2 medicine cis and/or trans isomers of 2,4-dioxohept-2-enoic acid might be diagnostic for human deficiency of maleylacetoacetate isomerase Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.2.1.2 expression in Escherichia coli Homo sapiens
5.2.1.2 expression in Escherichia coli Aspergillus nidulans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.2.1.2 Maleylacetoacetate Homo sapiens human maleylacetoacetate isomerase deficiency presumably causes tyrosinemia that can be characterized by the absence of succinylacetone ?
-
 ?
5.2.1.2 Maleylacetoacetate Aspergillus nidulans enzyme of the phenylacetate pathway ?
-
 ?
5.2.1.2 additional information Homo sapiens enzyme deficiency would presumably cause tyrosinemia that would be characterized by the absence of succinylacetone ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.2.1.2 Aspergillus nidulans
-
-
-
5.2.1.2 Aspergillus nidulans O43123
-
-
5.2.1.2 Homo sapiens
-
-
-
5.2.1.2 Homo sapiens O43708
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.2.1.2 Maleylacetoacetate human maleylacetoacetate isomerase deficiency presumably causes tyrosinemia that can be characterized by the absence of succinylacetone Homo sapiens ?
-
 ?
5.2.1.2 Maleylacetoacetate enzyme of the phenylacetate pathway Aspergillus nidulans ?
-
 ?
5.2.1.2 additional information enzyme deficiency would presumably cause tyrosinemia that would be characterized by the absence of succinylacetone Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.2.1.2 MAAI
-
 Aspergillus nidulans
5.2.1.2 MAAI
-
 Homo sapiens