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Literature summary extracted from

  • Gopal, P.; Sullivan, P.A.; Shepherd, M.G.
    Enzymes of N-acetylglucosamine metabolism during germ-tube formation in Candida albicans (1982), J. Gen. Microbiol., 128, 2319-2326.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.25 acetate no inhibition Candida albicans
3.5.1.25 fructose-6-phosphate 40 mM, 75% inhibition Candida albicans
3.5.1.25 glucosamine 6-phosphate competitive Candida albicans
3.5.1.25 UDP-N-acetylglucosamine 10 mM, 35% inhibition Candida albicans
3.5.1.25 UTP 7.5 mM, 21% inhibition Candida albicans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.25 N-acetyl-D-glucosamine 6-phosphate + H2O Candida albicans enzyme of the N-acetylglucosamine pathway D-glucosamine 6-phosphate + acetate
-
 ?
3.5.1.25 N-acetyl-D-glucosamine 6-phosphate + H2O Candida albicans inducible enzyme, trichodermin and lomofungin inhibit induction of the enzyme D-glucosamine 6-phosphate + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.25 Candida albicans
-
-
-

Storage Stability

EC Number Storage Stability Organism
3.5.1.25 4°C, 100 mM Tris/HCl, pH 7.2, stable for 1 week Candida albicans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.25 N-acetyl-D-glucosamine 6-phosphate + H2O
-
 Candida albicans D-glucosamine 6-phosphate + acetate
-
 ?
3.5.1.25 N-acetyl-D-glucosamine 6-phosphate + H2O enzyme of the N-acetylglucosamine pathway Candida albicans D-glucosamine 6-phosphate + acetate
-
 ?
3.5.1.25 N-acetyl-D-glucosamine 6-phosphate + H2O inducible enzyme, trichodermin and lomofungin inhibit induction of the enzyme Candida albicans D-glucosamine 6-phosphate + acetate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.25 8.5
-
-
 Candida albicans

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.5.1.25 7 9.5 more than 90% of maximal activity below pH 9.5 and above pH 7.0 Candida albicans