BRENDA - Enzyme Database show

Inhibition of nicotinamide deaminase from Micrococcus lysodeikticus by analogues of nicotinamide

Johnson, W.J.; Gadd, R.E.A.; Int. J. Biochem. 5, 633-641 (1974)
No PubMed abstract available

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.5.1.19
3-(3-pyridyl)-1-propanol
moderate
Micrococcus luteus
3.5.1.19
3-acetylpyridine
moderate
Micrococcus luteus
3.5.1.19
3-aminomethylpyridine
potent
Micrococcus luteus
3.5.1.19
3-chloropyridine
moderate
Micrococcus luteus
3.5.1.19
3-Cyanopyridine
potent
Micrococcus luteus
3.5.1.19
3-Pyridineacetonitrile
moderate
Micrococcus luteus
3.5.1.19
3-pyridinealdoxime
potent
Micrococcus luteus
3.5.1.19
3-Pyridinecarboxaldehyde
potent
Micrococcus luteus
3.5.1.19
3-Pyridylcarbinol
potent
Micrococcus luteus
3.5.1.19
4-aminonicotinamide
potent
Micrococcus luteus
3.5.1.19
5-Methylnicotinamide
moderate
Micrococcus luteus
3.5.1.19
isoniazid
moderate
Micrococcus luteus
3.5.1.19
additional information
pyridine nitrogen and the carbonyl carbon of nicotinamide are involved in substrate-enzyme binding, and the enzyme exhibits steric hindrance in binding nicotinamide analogues with substituents at the 1-position, 5-position, and 6-positions of the pyridine ring
Micrococcus luteus
3.5.1.19
nicotinal hydroxamic acid
moderate
Micrococcus luteus
3.5.1.19
nicotinic acid hydrazide
potent
Micrococcus luteus
3.5.1.19
nipecotamide
moderate
Micrococcus luteus
3.5.1.19
o-bromobenzamide
moderate
Micrococcus luteus
3.5.1.19
Pyrazinamide
moderate
Micrococcus luteus
3.5.1.19
Thionicotinamide
moderate
Micrococcus luteus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.5.1.19
Micrococcus luteus
-
i.e. Micrococcus lysodeiktikus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.1.19
nicotinamide + H2O
-
246574
Micrococcus luteus
nicotinate + NH3
-
-
-
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.5.1.19
3-(3-pyridyl)-1-propanol
moderate
Micrococcus luteus
3.5.1.19
3-acetylpyridine
moderate
Micrococcus luteus
3.5.1.19
3-aminomethylpyridine
potent
Micrococcus luteus
3.5.1.19
3-chloropyridine
moderate
Micrococcus luteus
3.5.1.19
3-Cyanopyridine
potent
Micrococcus luteus
3.5.1.19
3-Pyridineacetonitrile
moderate
Micrococcus luteus
3.5.1.19
3-pyridinealdoxime
potent
Micrococcus luteus
3.5.1.19
3-Pyridinecarboxaldehyde
potent
Micrococcus luteus
3.5.1.19
3-Pyridylcarbinol
potent
Micrococcus luteus
3.5.1.19
4-aminonicotinamide
potent
Micrococcus luteus
3.5.1.19
5-Methylnicotinamide
moderate
Micrococcus luteus
3.5.1.19
isoniazid
moderate
Micrococcus luteus
3.5.1.19
additional information
pyridine nitrogen and the carbonyl carbon of nicotinamide are involved in substrate-enzyme binding, and the enzyme exhibits steric hindrance in binding nicotinamide analogues with substituents at the 1-position, 5-position, and 6-positions of the pyridine ring
Micrococcus luteus
3.5.1.19
nicotinal hydroxamic acid
moderate
Micrococcus luteus
3.5.1.19
nicotinic acid hydrazide
potent
Micrococcus luteus
3.5.1.19
nipecotamide
moderate
Micrococcus luteus
3.5.1.19
o-bromobenzamide
moderate
Micrococcus luteus
3.5.1.19
Pyrazinamide
moderate
Micrococcus luteus
3.5.1.19
Thionicotinamide
moderate
Micrococcus luteus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.1.19
nicotinamide + H2O
-
246574
Micrococcus luteus
nicotinate + NH3
-
-
-
?