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Literature summary extracted from

  • Hagen, F.S.; Grant, F.J.; Kuijper, J.L.; Slaughter, C.A.; Moomaw, C.R.; Orth, K.; O'Hara, P.J.; Munford, R.S.
    Expression and characterization of recombinant human acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides (1991), Biochemistry, 30, 8415-8423.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.77 in BHK 570 cells Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.77 13800
-
 small subunit, calculated from sequence of unglycosylated protein Homo sapiens
3.1.1.77 14000 20000 small subunit, SDS-PAGE in presence of 2-mercaptoethanol Homo sapiens
3.1.1.77 47700
-
 large subunit, calculated from sequence of unglycosylated protein Homo sapiens
3.1.1.77 50000
-
 large subunit, SDS-PAGE in presence of 2-mercaptoethanol Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.77 3-(acyloxy)acyl group of bacterial toxin Homo sapiens detoxification of LPS 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.77 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.1.77 glycoprotein five potential glycosylation sites, one on the small and four on the large subunit Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.77 HL-60 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.77 3-(acyloxy)acyl group of bacterial toxin detoxification of LPS Homo sapiens 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
 ?
3.1.1.77 3-(acyloxy)acyl group of bacterial toxin + H2O
-
 Homo sapiens 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.77 dimer alpha, beta, 1 * 50000 + 1 * 14000-20000, disulfide linked Homo sapiens