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Literature summary extracted from

  • Donoghue, N.A.; Trudgill, P.W.
    The metabolism of cyclohexanol by Acinetobacter NCIB 9871 (1975), Eur. J. Biochem., 60, 1-7.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.245 cyclohexanol + NAD+ Acinetobacter sp. inducible cyclohexanone + NADH
-
 ?
1.1.1.245 cyclohexanol + NAD+ Acinetobacter sp. NCIB 9871 inducible cyclohexanone + NADH
-
 ?
1.1.1.258 6-hydroxyhexanoate + NAD+ Nocardia globerula
-
 6-oxohexanoate + NADH
-
 r
1.1.1.258 6-hydroxyhexanoate + NAD+ Acinetobacter sp. involved in the degradation pathway from cyclohexanol to adipate 6-oxohexanoate + NADH
-
 r
1.1.1.258 6-hydroxyhexanoate + NAD+ Acinetobacter sp. NCIB 9871 involved in the degradation pathway from cyclohexanol to adipate 6-oxohexanoate + NADH
-
 r
1.1.1.258 6-hydroxyhexanoate + NAD+ Nocardia globerula CL1
-
 6-oxohexanoate + NADH
-
 r
1.2.1.63 6-oxohexanoate + NADP+ + H2O Acinetobacter sp.
-
 adipate + NADPH
-
 ?
1.2.1.63 6-oxohexanoate + NADP+ + H2O Nocardia globerula
-
 adipate + NADPH
-
 ?
1.2.1.63 6-oxohexanoate + NADP+ + H2O Acinetobacter sp. NCIB 9871
-
 adipate + NADPH
-
 ?
1.2.1.63 6-oxohexanoate + NADP+ + H2O Nocardia globerula CL1
-
 adipate + NADPH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.245 Acinetobacter sp.
-
-
-
1.1.1.245 Acinetobacter sp. NCIB 9871
-
-
-
1.1.1.258 Acinetobacter sp.
-
-
-
1.1.1.258 Acinetobacter sp. NCIB 9871
-
-
-
1.1.1.258 Nocardia globerula
-
-
-
1.1.1.258 Nocardia globerula CL1
-
-
-
1.2.1.63 Acinetobacter sp.
-
-
-
1.2.1.63 Acinetobacter sp. NCIB 9871
-
-
-
1.2.1.63 Nocardia globerula
-
-
-
1.2.1.63 Nocardia globerula CL1
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.258 culture condition:cyclohexanol-grown cell induction of enzyme synthesis by growth in cyclohexanol containing medium Acinetobacter sp.
-
1.2.1.63 cell culture inducible enzyme synthesis by growth in cyclohexanol Acinetobacter sp.
-
1.2.1.63 cell culture inducible enzyme synthesis by growth in cyclohexanol Nocardia globerula
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.245 0.28
-
 cell extract at pH 10 Acinetobacter sp.
1.1.1.258 0.03
-
-
 Acinetobacter sp.

Storage Stability

EC Number Storage Stability Organism
1.1.1.258 very labile to storage Acinetobacter sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.245 cyclohexanol + NAD+
-
 Acinetobacter sp. cyclohexanone + NADH
-
 ?
1.1.1.245 cyclohexanol + NAD+ inducible Acinetobacter sp. cyclohexanone + NADH
-
 ?
1.1.1.245 cyclohexanol + NAD+
-
 Acinetobacter sp. NCIB 9871 cyclohexanone + NADH
-
 ?
1.1.1.245 cyclohexanol + NAD+ inducible Acinetobacter sp. NCIB 9871 cyclohexanone + NADH
-
 ?
1.1.1.258 6-hydroxyhexanoate + NAD+
-
 Nocardia globerula 6-oxohexanoate + NADH
-
 r
1.1.1.258 6-hydroxyhexanoate + NAD+ involved in the degradation pathway from cyclohexanol to adipate Acinetobacter sp. 6-oxohexanoate + NADH
-
 r
1.1.1.258 6-hydroxyhexanoate + NAD+ involved in the degradation pathway from cyclohexanol to adipate Acinetobacter sp. NCIB 9871 6-oxohexanoate + NADH
-
 r
1.1.1.258 6-hydroxyhexanoate + NAD+
-
 Nocardia globerula CL1 6-oxohexanoate + NADH
-
 r
1.2.1.63 6-oxohexanoate + NADP+ + H2O
-
 Acinetobacter sp. adipate + NADPH
-
 ?
1.2.1.63 6-oxohexanoate + NADP+ + H2O
-
 Nocardia globerula adipate + NADPH
-
 ?
1.2.1.63 6-oxohexanoate + NADP+ + H2O
-
 Acinetobacter sp. NCIB 9871 adipate + NADPH
-
 ?
1.2.1.63 6-oxohexanoate + NADP+ + H2O
-
 Nocardia globerula CL1 adipate + NADPH
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.245 NAD+
-
 Acinetobacter sp.
1.1.1.258 NAD+ can not be replaced by NADP+ Acinetobacter sp.
1.2.1.63 NADP+ can not replaced by NAD+ Acinetobacter sp.