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Literature summary extracted from

  • Lu, J.Y.; Verkruyse, L.A.; Hofmann, S.L.
    Lipid thioesters derived from acylated proteins accumulate in infantile neuronal ceroid lipofuscinosis: correction of the defect in lymphoblasts by recombinant palmitoyl-protein thioesterase (1996), Proc. Natl. Acad. Sci. USA, 93, 10046-10050.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.22 lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.22 additional information Homo sapiens mutations in the enzyme protein cause the neurodegenerative disorder infantile neuronal ceroid lipofuscinosis ?
-
 ?
3.1.2.22 additional information Homo sapiens the enzyme is required for the efficient lysosomal degradation of thioesters derived from S-acylated proteins ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.22 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.22 additional information mutations in the enzyme protein cause the neurodegenerative disorder infantile neuronal ceroid lipofuscinosis Homo sapiens ?
-
 ?
3.1.2.22 additional information the enzyme is required for the efficient lysosomal degradation of thioesters derived from S-acylated proteins Homo sapiens ?
-
 ?
3.1.2.22 palmitoyl-[protein] + H2O
-
 Homo sapiens palmitate + protein
-
 ?