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Literature summary extracted from

  • Abbott, S.D.; Lane-Bell, P.; Sidhu, K.P.S.; Vederas, J.C.
    Synthesis and testing of heterocyclic analogues of diaminopimelic acid (DAP) as inhibitors of DAP dehydrogenase and DAP epimerase (1994), J. Am. Chem. Soc., 116, 6513-6520.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.1.16 (2S,5S)-2-amino-3(3-carboxy-2-isoxazolin-5-yl)propanoic acid competitive inhibition Lysinibacillus sphaericus
5.1.1.7 additional information none of the following compounds shows significant inhibition: (2S)-2-amino-3-(4-carboxyimidazol-1-yl)propanoic acid, (2S,5'R)-2-amino-3-(3-carboxy-2-isoxazolin-5-yl)propanoic acid and its 5'S diastereomer, 2-isoxazoline-3-carboxylic acid, and 2-isoxazoline-3,5-dicarboxylic acid Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
1.4.1.16 Lysinibacillus sphaericus
-
-
-
5.1.1.7 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.1.1.7
-
Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.1.16 L-2-amino-6-oxoheptanedioate + NH3 + NAD(P)H
-
Lysinibacillus sphaericus meso-2,6-diaminoheptanedioate + H2O + NAD(P)+
-
r
5.1.1.7 LL-2,6-Diaminoheptanedioate
-
Escherichia coli meso-Diaminoheptanedioate
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.1.16 NADPH
-
Lysinibacillus sphaericus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.1.16 0.0042
-
(2S,5S)-2-amino-3(3-carboxy-2-isoxazolin-5-yl)propanoic acid competitive inhibition of L-2-amino-6-oxoheptanedioate Lysinibacillus sphaericus
1.4.1.16 0.023
-
(2S,5S)-2-amino-3(3-carboxy-2-isoxazolin-5-yl)propanoic acid noncompetitive inhibition of meso-diaminopimelate Lysinibacillus sphaericus