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Literature summary extracted from

  • Lam, L.K.P.; Arnold, L.D.; Kalantar, T.H.; Kelland, J.G.; Lane-Bell, P.M.; Palcic, M.M.; Pickard, M.A.; Vederas, J.C.
    Analogs of diaminopimelic acid as inhibitors of meso-diaminopimelate dehydrogenase and LL-diaminopimelate epimerase (1988), J. Biol. Chem., 263, 11814-11819.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.1.1.7 Lanthionine isomers
-
 Escherichia coli
5.1.1.7 Lanthionine sulfone
-
 Escherichia coli
5.1.1.7 Lanthionine sulfoxide
-
 Escherichia coli
5.1.1.7 N-Aminodiaminopimelate
-
 Escherichia coli
5.1.1.7 N-Hydroxydiaminopimelate
-
 Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
1.4.1.16 Lysinibacillus sphaericus
-
-
-
5.1.1.7 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.1.1.7
-
 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.1.16 2,6-diaminoheptanedioic acid + H2O + NADP+ mixture of all possible stereoisomers, 4% of activity with meso-2,6-diaminopimelate Lysinibacillus sphaericus 2-amino-6-oxopimelate + NH3 + NADPH
-
 r
1.4.1.16 2-amino-6-(hydroxyamino)heptanedioic acid + H2O + NADP+ mixture of all possible stereoisomers, 22% of activity with meso-2,6-diaminopimelate Lysinibacillus sphaericus 2-hydroxyamino-6-oxopimelate + NH3 + NADPH
-
 r
1.4.1.16 4-methylene diaminopimelate + H2O + NADP+ mixture of all possible stereoisomers, 4% of activity with meso-2,6-diaminopimelate Lysinibacillus sphaericus 4-methyleneamino-6-oxopimelate + NH3 + NADPH
-
 r
1.4.1.16 L-2-amino-6-oxoheptanedioate + NH3 + NAD(P)H
-
 Lysinibacillus sphaericus meso-2,6-diaminoheptanedioate + H2O + NAD(P)+
-
 r
5.1.1.7 LL-2,6-Diaminoheptanedioate
-
 Escherichia coli meso-Diaminoheptanedioate
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.1.16 NADPH
-
 Lysinibacillus sphaericus