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Literature summary extracted from
- Serine dehydratase in animal tissues (1973), Acta Vitaminol. Enzymol., 27, 51-61.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.3.1.18 | ATP | activation at low concentrations, inhibition at high concentrations | Gallus gallus |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.3.1.17 | 70 | - |
L-Ser | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.3.1.18 | soluble | - |
Gallus gallus | - |
- |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.3.1.17 | 34000 | - |
2 * 34000 | Rattus norvegicus |
| 4.3.1.17 | 63500 | - |
- |
Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.3.1.17 | Gallus gallus | - |
- |
- |
| 4.3.1.17 | Rattus norvegicus | - |
- |
- |
| 4.3.1.18 | Gallus gallus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.3.1.18 | - |
Gallus gallus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.3.1.17 | kidney | - |
Gallus gallus | - |
| 4.3.1.17 | liver | - |
Gallus gallus | - |
| 4.3.1.17 | liver | - |
Rattus norvegicus | - |
| 4.3.1.18 | kidney | - |
Gallus gallus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.3.1.17 | L-serine | - |
Gallus gallus | pyruvate + NH3 | - |
? | |
| 4.3.1.17 | L-serine | - |
Rattus norvegicus | pyruvate + NH3 | - |
? | |
| 4.3.1.18 | D-serine | - |
Gallus gallus | pyruvate + NH3 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.3.1.17 | dimer | 2 * 34000 | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.3.1.17 | 8.6 | - |
- |
Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.3.1.17 | pyridoxal 5'-phosphate | one mol of enzyme contains two mol of pyridoxal phosphate | Rattus norvegicus | |
| 4.3.1.17 | pyridoxal 5'-phosphate | Km: 0.0003 mM | Rattus norvegicus | |
| 4.3.1.18 | AMP | activates | Gallus gallus | |
| 4.3.1.18 | ATP | activation at low concentrations, inhibition at high concentrations | Gallus gallus | |
| 4.3.1.18 | CMP | activates | Gallus gallus | |
| 4.3.1.18 | IMP | activates | Gallus gallus | |
| 4.3.1.18 | UMP | activates | Gallus gallus | |
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Release 2023.1 (January 2023)
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