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Assessment of the active-site requirements of 5-aminolevulinic acid dehydratase: evaluation of substrate and product analogues as competitive inhibitors

Luond, R.M.; Walker, J.; Neier, R.W.; J. Org. Chem. 57, 5005-5013 (1992)
No PubMed abstract available

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.24
4-nitro-2-butanone
-
Rhodobacter sphaeroides
4.2.1.24
5-hydroxy-4-oxopentanoic acid
-
Rhodobacter sphaeroides
4.2.1.24
5-nitrilo-4-oxopentanoic acid
-
Rhodobacter sphaeroides
4.2.1.24
rac-2-hydroxy-4-oxopentanoic acid
-
Rhodobacter sphaeroides
4.2.1.24
rac-3-hydroxy-4-oxopentanoic acid
-
Rhodobacter sphaeroides
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.2.1.24
Rhodobacter sphaeroides
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.24
5-aminolevulinate + 5-aminolevulinate
-
210719
Rhodobacter sphaeroides
porphobilinogen + 2 H2O
-
210719
Rhodobacter sphaeroides
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.24
4-nitro-2-butanone
-
Rhodobacter sphaeroides
4.2.1.24
5-hydroxy-4-oxopentanoic acid
-
Rhodobacter sphaeroides
4.2.1.24
5-nitrilo-4-oxopentanoic acid
-
Rhodobacter sphaeroides
4.2.1.24
rac-2-hydroxy-4-oxopentanoic acid
-
Rhodobacter sphaeroides
4.2.1.24
rac-3-hydroxy-4-oxopentanoic acid
-
Rhodobacter sphaeroides
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.24
5-aminolevulinate + 5-aminolevulinate
-
210719
Rhodobacter sphaeroides
porphobilinogen + 2 H2O
-
210719
Rhodobacter sphaeroides
?