BRENDA - Enzyme Database show

Inhibition of delta-aminolaevulate dehydratase by pyridoxal derivatives and by cyanide

Van Heyningen, S.; Shemin, D.; Biochem. J. 124, 68P (1971)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.24
levulate
-
Rhodobacter sphaeroides
4.2.1.24
NaCN
competitive
Rhodobacter sphaeroides
4.2.1.24
pyridoxal
-
Rhodobacter sphaeroides
4.2.1.24
pyridoxal 5'-phosphate
30% inhibition at 1 mM, negligible inhibition at 0.05 mM
Rhodobacter sphaeroides
4.2.1.24
pyridoxamine phosphate
-
Rhodobacter sphaeroides
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
4.2.1.24
0.8
-
5-aminolevulinate
-
Rhodobacter sphaeroides
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.2.1.24
Rhodobacter sphaeroides
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.24
5-aminolevulinate + 5-aminolevulinate
-
210711
Rhodobacter sphaeroides
porphobilinogen + 2 H2O
-
210711
Rhodobacter sphaeroides
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.24
levulate
-
Rhodobacter sphaeroides
4.2.1.24
NaCN
competitive
Rhodobacter sphaeroides
4.2.1.24
pyridoxal
-
Rhodobacter sphaeroides
4.2.1.24
pyridoxal 5'-phosphate
30% inhibition at 1 mM, negligible inhibition at 0.05 mM
Rhodobacter sphaeroides
4.2.1.24
pyridoxamine phosphate
-
Rhodobacter sphaeroides
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
4.2.1.24
0.8
-
5-aminolevulinate
-
Rhodobacter sphaeroides
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.24
5-aminolevulinate + 5-aminolevulinate
-
210711
Rhodobacter sphaeroides
porphobilinogen + 2 H2O
-
210711
Rhodobacter sphaeroides
?