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Literature summary extracted from

  • Certad, G.; Abrahem, A.; Georges, E.
    Cloning and partial characterization of the proteasome S4 ATPase from Plasmodium falciparum (1999), Exp. Parasitol., 93, 123-131.
    View publication on PubMed

Application

EC Number Application Comment Organism
5.6.1.5 medicine molecular analysis of this parasite, new means to combat drug resistance in malaria, PSF4 may be a target for the development of new antimalarial drugs that will be effective against chloroquine-resistant parasites Plasmodium falciparum

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.6.1.5 cloning of a cDNA encoding the proteasome subunit 4 ATPase, gene PSF4, PCR and DNA sequencing Plasmodium falciparum

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
5.6.1.5
-
Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.1.5 lactacystin
-
Entamoeba histolytica
5.6.1.5 lactacystin specific inhibitor of the eukaryotic proteasome Plasmodium falciparum
5.6.1.5 lactacystin
-
Trypanosoma cruzi

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.6.1.5 cytosol
-
Plasmodium falciparum 5829
-
5.6.1.5 nucleus
-
Homo sapiens 5634
-
5.6.1.5 nucleus
-
Saccharomyces cerevisiae 5634
-
5.6.1.5 nucleus
-
Plasmodium falciparum 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.6.1.5 50000
-
S4 ATPase, SDS-PAGE Plasmodium falciparum
5.6.1.5 700000
-
regulatory complex PA700 Saccharomyces cerevisiae
5.6.1.5 2000000
-
26S proteasome, ATP-dependent proteolytic complex Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.1.5 ATP + H2O + polypeptide Drosophila sp. (in: flies)
-
ADP + phosphate + unfolded polypeptide
-
?
5.6.1.5 ATP + H2O + polypeptide Mus musculus
-
ADP + phosphate + unfolded polypeptide
-
?
5.6.1.5 ATP + H2O + polypeptide Homo sapiens
-
ADP + phosphate + unfolded polypeptide
-
?
5.6.1.5 ATP + H2O + polypeptide Saccharomyces cerevisiae
-
ADP + phosphate + unfolded polypeptide
-
?
5.6.1.5 ATP + H2O + polypeptide Entamoeba histolytica
-
ADP + phosphate + unfolded polypeptide
-
?
5.6.1.5 ATP + H2O + polypeptide Trypanosoma cruzi
-
ADP + phosphate + unfolded polypeptide
-
?
5.6.1.5 ATP + H2O + polypeptide Plasmodium falciparum
-
ADP + phosphate + unfolded polypeptide
-
?
5.6.1.5 ATP + H2O + polypeptide Oryza sativa
-
ADP + phosphate + unfolded polypeptide
-
?

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.5 Drosophila sp. (in: flies)
-
-
-
5.6.1.5 Entamoeba histolytica
-
-
-
5.6.1.5 Homo sapiens
-
-
-
5.6.1.5 Mus musculus
-
mouse
-
5.6.1.5 Oryza sativa
-
rice
-
5.6.1.5 Plasmodium falciparum
-
most lethal form of human malaria
-
5.6.1.5 Saccharomyces cerevisiae
-
-
-
5.6.1.5 Trypanosoma cruzi
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
5.6.1.5 ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Drosophila sp. (in: flies)
5.6.1.5 ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Mus musculus
5.6.1.5 ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Homo sapiens
5.6.1.5 ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Saccharomyces cerevisiae
5.6.1.5 ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Entamoeba histolytica
5.6.1.5 ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Trypanosoma cruzi
5.6.1.5 ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Plasmodium falciparum
5.6.1.5 ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Oryza sativa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.5 ATP + H2O + polypeptide
-
Drosophila sp. (in: flies) ADP + phosphate + unfolded polypeptide
-
?
5.6.1.5 ATP + H2O + polypeptide
-
Mus musculus ADP + phosphate + unfolded polypeptide
-
?
5.6.1.5 ATP + H2O + polypeptide
-
Homo sapiens ADP + phosphate + unfolded polypeptide
-
?
5.6.1.5 ATP + H2O + polypeptide
-
Saccharomyces cerevisiae ADP + phosphate + unfolded polypeptide
-
?
5.6.1.5 ATP + H2O + polypeptide
-
Entamoeba histolytica ADP + phosphate + unfolded polypeptide
-
?
5.6.1.5 ATP + H2O + polypeptide
-
Trypanosoma cruzi ADP + phosphate + unfolded polypeptide
-
?
5.6.1.5 ATP + H2O + polypeptide
-
Plasmodium falciparum ADP + phosphate + unfolded polypeptide
-
?
5.6.1.5 ATP + H2O + polypeptide
-
Oryza sativa ADP + phosphate + unfolded polypeptide
-
?

Synonyms

EC Number Synonyms Comment Organism
5.6.1.5 26S proteasome
-
Homo sapiens
5.6.1.5 26S proteasome
-
Saccharomyces cerevisiae
5.6.1.5 26S proteasome
-
Plasmodium falciparum
5.6.1.5 proteasome S4 ATPase
-
Drosophila sp. (in: flies)
5.6.1.5 proteasome S4 ATPase
-
Mus musculus
5.6.1.5 proteasome S4 ATPase
-
Homo sapiens
5.6.1.5 proteasome S4 ATPase
-
Saccharomyces cerevisiae
5.6.1.5 proteasome S4 ATPase
-
Plasmodium falciparum
5.6.1.5 proteasome S4 ATPase
-
Oryza sativa