EC Number | Application | Comment | Organism |
---|---|---|---|
5.6.1.5 | medicine | molecular analysis of this parasite, new means to combat drug resistance in malaria, PSF4 may be a target for the development of new antimalarial drugs that will be effective against chloroquine-resistant parasites | Plasmodium falciparum |
EC Number | Cloned (Comment) | Organism |
---|---|---|
5.6.1.5 | cloning of a cDNA encoding the proteasome subunit 4 ATPase, gene PSF4, PCR and DNA sequencing | Plasmodium falciparum |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
5.6.1.5 | - |
Saccharomyces cerevisiae |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
5.6.1.5 | lactacystin | - |
Entamoeba histolytica | |
5.6.1.5 | lactacystin | specific inhibitor of the eukaryotic proteasome | Plasmodium falciparum | |
5.6.1.5 | lactacystin | - |
Trypanosoma cruzi |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
5.6.1.5 | cytosol | - |
Plasmodium falciparum | 5829 | - |
5.6.1.5 | nucleus | - |
Homo sapiens | 5634 | - |
5.6.1.5 | nucleus | - |
Saccharomyces cerevisiae | 5634 | - |
5.6.1.5 | nucleus | - |
Plasmodium falciparum | 5634 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
5.6.1.5 | 50000 | - |
S4 ATPase, SDS-PAGE | Plasmodium falciparum |
5.6.1.5 | 700000 | - |
regulatory complex PA700 | Saccharomyces cerevisiae |
5.6.1.5 | 2000000 | - |
26S proteasome, ATP-dependent proteolytic complex | Plasmodium falciparum |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.6.1.5 | ATP + H2O + polypeptide | Drosophila sp. (in: flies) | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
5.6.1.5 | ATP + H2O + polypeptide | Mus musculus | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
5.6.1.5 | ATP + H2O + polypeptide | Homo sapiens | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
5.6.1.5 | ATP + H2O + polypeptide | Saccharomyces cerevisiae | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
5.6.1.5 | ATP + H2O + polypeptide | Entamoeba histolytica | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
5.6.1.5 | ATP + H2O + polypeptide | Trypanosoma cruzi | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
5.6.1.5 | ATP + H2O + polypeptide | Plasmodium falciparum | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
5.6.1.5 | ATP + H2O + polypeptide | Oryza sativa | - |
ADP + phosphate + unfolded polypeptide | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.6.1.5 | Drosophila sp. (in: flies) | - |
- |
- |
5.6.1.5 | Entamoeba histolytica | - |
- |
- |
5.6.1.5 | Homo sapiens | - |
- |
- |
5.6.1.5 | Mus musculus | - |
mouse | - |
5.6.1.5 | Oryza sativa | - |
rice | - |
5.6.1.5 | Plasmodium falciparum | - |
most lethal form of human malaria | - |
5.6.1.5 | Saccharomyces cerevisiae | - |
- |
- |
5.6.1.5 | Trypanosoma cruzi | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
5.6.1.5 | ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Drosophila sp. (in: flies) | |
5.6.1.5 | ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Mus musculus | |
5.6.1.5 | ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Homo sapiens | |
5.6.1.5 | ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Saccharomyces cerevisiae | |
5.6.1.5 | ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Entamoeba histolytica | |
5.6.1.5 | ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Trypanosoma cruzi | |
5.6.1.5 | ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Plasmodium falciparum | |
5.6.1.5 | ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Oryza sativa |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.6.1.5 | ATP + H2O + polypeptide | - |
Drosophila sp. (in: flies) | ADP + phosphate + unfolded polypeptide | - |
? | |
5.6.1.5 | ATP + H2O + polypeptide | - |
Mus musculus | ADP + phosphate + unfolded polypeptide | - |
? | |
5.6.1.5 | ATP + H2O + polypeptide | - |
Homo sapiens | ADP + phosphate + unfolded polypeptide | - |
? | |
5.6.1.5 | ATP + H2O + polypeptide | - |
Saccharomyces cerevisiae | ADP + phosphate + unfolded polypeptide | - |
? | |
5.6.1.5 | ATP + H2O + polypeptide | - |
Entamoeba histolytica | ADP + phosphate + unfolded polypeptide | - |
? | |
5.6.1.5 | ATP + H2O + polypeptide | - |
Trypanosoma cruzi | ADP + phosphate + unfolded polypeptide | - |
? | |
5.6.1.5 | ATP + H2O + polypeptide | - |
Plasmodium falciparum | ADP + phosphate + unfolded polypeptide | - |
? | |
5.6.1.5 | ATP + H2O + polypeptide | - |
Oryza sativa | ADP + phosphate + unfolded polypeptide | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.6.1.5 | 26S proteasome | - |
Homo sapiens |
5.6.1.5 | 26S proteasome | - |
Saccharomyces cerevisiae |
5.6.1.5 | 26S proteasome | - |
Plasmodium falciparum |
5.6.1.5 | proteasome S4 ATPase | - |
Drosophila sp. (in: flies) |
5.6.1.5 | proteasome S4 ATPase | - |
Mus musculus |
5.6.1.5 | proteasome S4 ATPase | - |
Homo sapiens |
5.6.1.5 | proteasome S4 ATPase | - |
Saccharomyces cerevisiae |
5.6.1.5 | proteasome S4 ATPase | - |
Plasmodium falciparum |
5.6.1.5 | proteasome S4 ATPase | - |
Oryza sativa |