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Literature summary extracted from

  • Fukuda, S.; Shimozawa, N.; Suzuki, Y.; Zhang, Z.; Tomatsu, S.; Tsukamoto, T.; Hashiguchi, N.; Osumi, T.; Masuno, M.; Imaizumi, K.; Kuroki, Y.; Fujiki, Y.; Orii, T.; Kondo, N.
    Human peroxisome assembly factor-2 (PAF-2): a gene responsible for group C peroxisome biogenesis disorder in humans (1996), Am. J. Hum. Genet., 59, 1210-1220.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.6.4.7 medicine
-
 Cricetulus griseus
3.6.4.7 medicine
-
 Rattus norvegicus
3.6.4.7 medicine development of gene therapy, restoring of peroxisome assemblyby gene transfer to fibroblasts of Zellweger syndrome group C patients Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.4.7 PCR amplification, full-length human PAF-2 cDNA cloned Homo sapiens
3.6.4.7 peroxisome assembly factor-2 cloned from rat cDNA Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.4.7 ATP + H2O Cricetulus griseus
-
 ADP + phosphate
-
 ?
3.6.4.7 ATP + H2O Homo sapiens
-
 ADP + phosphate
-
 ?
3.6.4.7 ATP + H2O Rattus norvegicus
-
 ADP + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.4.7 Cricetulus griseus
-
 chinese hamster
-
3.6.4.7 Homo sapiens
-
 human
-
3.6.4.7 Rattus norvegicus
-
 rat
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.6.4.7 ATP + H2O = ADP + phosphate an extremely diversified group of enzymes that use the energy of ATP hydrolysis to import and assemble peroxisome components into the organelle. Their molecular masses range from 25 to 600 kDa Cricetulus griseus
a
3.6.4.7 ATP + H2O = ADP + phosphate an extremely diversified group of enzymes that use the energy of ATP hydrolysis to import and assemble peroxisome components into the organelle. Their molecular masses range from 25 to 600 kDa Homo sapiens
a
3.6.4.7 ATP + H2O = ADP + phosphate an extremely diversified group of enzymes that use the energy of ATP hydrolysis to import and assemble peroxisome components into the organelle. Their molecular masses range from 25 to 600 kDa Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.4.7 fibroblast
-
 Homo sapiens
-
3.6.4.7 liver
-
 Homo sapiens
-
3.6.4.7 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.4.7 ATP + H2O
-
 Cricetulus griseus ADP + phosphate
-
 ?
3.6.4.7 ATP + H2O
-
 Homo sapiens ADP + phosphate
-
 ?
3.6.4.7 ATP + H2O
-
 Rattus norvegicus ADP + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.4.7 PAF-2
-
 Homo sapiens
3.6.4.7 PAF-2
-
 Rattus norvegicus