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Literature summary extracted from
- A 200-amino acid ATPase module in search of a basic function (1995), Bioessays, 17, 639-650.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.6.4.6 | endoplasmic reticulum | - |
Drosophila melanogaster | 5783 | - |
| 3.6.4.6 | endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| 3.6.4.6 | endoplasmic reticulum | - |
Saccharomyces cerevisiae | 5783 | - |
| 3.6.4.6 | Golgi apparatus | - |
Drosophila melanogaster | 5794 | - |
| 3.6.4.6 | Golgi apparatus | - |
Homo sapiens | 5794 | - |
| 3.6.4.6 | Golgi apparatus | - |
Saccharomyces cerevisiae | 5794 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.4.6 | ATP + H2O | Drosophila melanogaster | - |
ADP + phosphate | - |
? |  |
| 3.6.4.6 | ATP + H2O | Mus musculus | - |
ADP + phosphate | - |
? | |
| 3.6.4.6 | ATP + H2O | Homo sapiens | - |
ADP + phosphate | - |
? | |
| 3.6.4.6 | ATP + H2O | Saccharomyces cerevisiae | - |
ADP + phosphate | - |
? | |
| 3.6.4.6 | ATP + H2O | Sulfolobus acidocaldarius | - |
ADP + phosphate | - |
? | |
| 3.6.4.6 | ATP + H2O | Xenopus laevis | - |
ADP + phosphate | - |
? | |
| 3.6.4.6 | ATP + H2O | Candida albicans | - |
ADP + phosphate | - |
? | |
| 3.6.4.6 | ATP + H2O | Cricetulus longicaudatus | - |
ADP + phosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.6.4.6 | Candida albicans | - |
- |
- |
| 3.6.4.6 | Cricetulus longicaudatus | - |
long-tailed hamster | - |
| 3.6.4.6 | Drosophila melanogaster | - |
- |
- |
| 3.6.4.6 | Homo sapiens | - |
human | - |
| 3.6.4.6 | Mus musculus | - |
- |
- |
| 3.6.4.6 | Saccharomyces cerevisiae | - |
- |
- |
| 3.6.4.6 | Sulfolobus acidocaldarius | - |
- |
- |
| 3.6.4.6 | Xenopus laevis | - |
- |
- |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 3.6.4.6 | ATP + H2O = ADP + phosphate | large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger 's syndrome. | Drosophila melanogaster | |
| 3.6.4.6 | ATP + H2O = ADP + phosphate | large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger 's syndrome. | Mus musculus | |
| 3.6.4.6 | ATP + H2O = ADP + phosphate | large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger 's syndrome. | Homo sapiens | |
| 3.6.4.6 | ATP + H2O = ADP + phosphate | large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger 's syndrome. | Saccharomyces cerevisiae | |
| 3.6.4.6 | ATP + H2O = ADP + phosphate | large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger 's syndrome. | Sulfolobus acidocaldarius | |
| 3.6.4.6 | ATP + H2O = ADP + phosphate | large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger 's syndrome. | Xenopus laevis | |
| 3.6.4.6 | ATP + H2O = ADP + phosphate | large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger 's syndrome. | Candida albicans | |
| 3.6.4.6 | ATP + H2O = ADP + phosphate | large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger 's syndrome. | Cricetulus longicaudatus |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.6.4.6 | 0.083 | - |
- |
Xenopus laevis |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.4.6 | ATP + H2O | - |
Drosophila melanogaster | ADP + phosphate | - |
? | |
| 3.6.4.6 | ATP + H2O | - |
Mus musculus | ADP + phosphate | - |
? | |
| 3.6.4.6 | ATP + H2O | - |
Homo sapiens | ADP + phosphate | - |
? | |
| 3.6.4.6 | ATP + H2O | - |
Saccharomyces cerevisiae | ADP + phosphate | - |
? | |
| 3.6.4.6 | ATP + H2O | - |
Sulfolobus acidocaldarius | ADP + phosphate | - |
? | |
| 3.6.4.6 | ATP + H2O | - |
Xenopus laevis | ADP + phosphate | - |
? | |
| 3.6.4.6 | ATP + H2O | - |
Candida albicans | ADP + phosphate | - |
? | |
| 3.6.4.6 | ATP + H2O | - |
Cricetulus longicaudatus | ADP + phosphate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.6.4.6 | oligomer | - |
Xenopus laevis |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.6.4.6 | dNSF | - |
Drosophila melanogaster |
| 3.6.4.6 | NSF protein | - |
Saccharomyces cerevisiae |
| 3.6.4.6 | NSF protein | N-ethyl-maleimide-sensitive fusion protein | Drosophila melanogaster |
| 3.6.4.6 | NSF protein | N-ethyl-maleimide-sensitive fusion protein | Homo sapiens |
| 3.6.4.6 | p97ATPase | - |
Xenopus laevis |
| 3.6.4.6 | SEC18 gene product | - |
Saccharomyces cerevisiae |
| 3.6.4.6 | SEC18 gene product | - |
Candida albicans |
| 3.6.4.6 | SKD2 | - |
Mus musculus |
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