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Literature summary extracted from

  • Blocker, A.; Severin, F.F.; Burkhardt, J.K.; Bingham, J.B.; Yu, H.; Olivo, J.C.; Schroer, T.A.; Hyman, A.A.; Griffiths, G.
    Molecular requirements for bi-directional movement of phagosomes along microtubules (1997), J. Cell Biol., 137, 113-129.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.6.1.2 cytoplasm
-
 Mus musculus 5737
-
5.6.1.2 phagosome cytoplasmic dynein localizes to phagosomes in vivo Mus musculus
-
-
5.6.1.3 cytoplasm
-
 Mus musculus 5737
-
5.6.1.3 phagosome cytoplasmic kinesin localizes to phagosomes in vivo Mus musculus
-
-
5.6.1.4 cytoplasm
-
 Mus musculus 5737
-
5.6.1.4 cytoplasm
-
 Rattus norvegicus 5737
-
5.6.1.4 cytoplasm
-
 Bos taurus 5737
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.6.1.4 74000
-
 gel filtration Mus musculus
5.6.1.4 74000
-
 gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.1.2 ATP + H2O + a dynein associated with a microtubule at position n Mus musculus the majority of moving phagosomes are minus-end directed, the remainder moves towards microtubule plus-ends and a small subset moves bi-directionally. Minus-end movement showes pharmacological characteristics expected for dyneins, plus-end movement displayed pharmacological properties of kinesin ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?
5.6.1.3 ATP + H2O + a kinesin associated with a microtubule at position n Mus musculus the majority of moving phagosomes are minus-end directed, the remainder moves towards microtubule plus-ends and a small subset moves bi-directionally. Minus-end movement showes pharmacological characteristics expected for dyneins, plus-end movement displayed pharmacological properties of kinesin ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
5.6.1.4 ATP + H2O + a kinesin associated with a microtubule at position n Gallus gallus
-
 ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?
5.6.1.4 ATP + H2O + a kinesin associated with a microtubule at position n Mus musculus
-
 ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?
5.6.1.4 ATP + H2O + a kinesin associated with a microtubule at position n Rattus norvegicus
-
 ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?
5.6.1.4 ATP + H2O + a kinesin associated with a microtubule at position n Bos taurus
-
 ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.2 Mus musculus
-
-
-
5.6.1.3 Mus musculus
-
-
-
5.6.1.4 Bos taurus
-
-
-
5.6.1.4 Gallus gallus
-
 chicken, cell line HD-11
-
5.6.1.4 Mus musculus
-
 mouse, strain J774
-
5.6.1.4 Rattus norvegicus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
5.6.1.4 ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end) structurally almost identical to EC3.6.4.3 (microtubule-severing ATPase) but the movement it catalyses is towards the minus end of microtubules Gallus gallus
a
5.6.1.4 ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end) structurally almost identical to EC3.6.4.3 (microtubule-severing ATPase) but the movement it catalyses is towards the minus end of microtubules Mus musculus
a
5.6.1.4 ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end) structurally almost identical to EC3.6.4.3 (microtubule-severing ATPase) but the movement it catalyses is towards the minus end of microtubules Rattus norvegicus
a
5.6.1.4 ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end) structurally almost identical to EC3.6.4.3 (microtubule-severing ATPase) but the movement it catalyses is towards the minus end of microtubules Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.1.2 J774 cell
-
 Mus musculus
-
5.6.1.3 J774 cell
-
 Mus musculus
-
5.6.1.4 brain
-
 Rattus norvegicus
-
5.6.1.4 brain
-
 Bos taurus
-
5.6.1.4 kidney
-
 Rattus norvegicus
-
5.6.1.4 macrophage
-
 Gallus gallus
-
5.6.1.4 macrophage
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.2 ATP + H2O + a dynein associated with a microtubule at position n
-
 Mus musculus ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?
5.6.1.2 ATP + H2O + a dynein associated with a microtubule at position n the majority of moving phagosomes are minus-end directed, the remainder moves towards microtubule plus-ends and a small subset moves bi-directionally. Minus-end movement showes pharmacological characteristics expected for dyneins, plus-end movement displayed pharmacological properties of kinesin Mus musculus ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?
5.6.1.3 ATP + H2O + a kinesin associated with a microtubule at position n
-
 Mus musculus ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
5.6.1.3 ATP + H2O + a kinesin associated with a microtubule at position n the majority of moving phagosomes are minus-end directed, the remainder moves towards microtubule plus-ends and a small subset moves bi-directionally. Minus-end movement showes pharmacological characteristics expected for dyneins, plus-end movement displayed pharmacological properties of kinesin Mus musculus ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
5.6.1.4 ATP + H2O + a kinesin associated with a microtubule at position n
-
 Gallus gallus ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?
5.6.1.4 ATP + H2O + a kinesin associated with a microtubule at position n
-
 Mus musculus ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?
5.6.1.4 ATP + H2O + a kinesin associated with a microtubule at position n
-
 Rattus norvegicus ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?
5.6.1.4 ATP + H2O + a kinesin associated with a microtubule at position n
-
 Bos taurus ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?