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Literature summary extracted from

  • Santama, N.; Krijnse-Locker, J.; Griffiths, G.; Noda, Y.; Hirokawa, N.; Dotti, C.G.
    KIF2beta, a new kinesin superfamily protein in non-neuronal cells, is associated with lysosomes and may be implicated in their centrifugal translocation (1998), EMBO J., 17, 5855-5867.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
5.6.1.3 medicine appears tempting to test whether blocking KIF2beta expression in host cells may inhibit parasite entry without affecting host cell viability, KIF2beta antisense oligonucleotides could act as preventive agents for parasite infection Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.6.1.3 KIF2beta cDNA PCR amplified and cloned Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.6.1.3 cytoplasm
-
 Mus musculus 5737
-
5.6.1.3 endoplasmic reticulum
-
 Mus musculus 5783
-
5.6.1.3 endoplasmic reticulum
-
 Homo sapiens 5783
-
5.6.1.3 nucleus
-
 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.1.3 ATP + H2O + a kinesin associated with a microtubule at position n Cricetulus griseus
-
 ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
5.6.1.3 ATP + H2O + a kinesin associated with a microtubule at position n Mus musculus
-
 ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
5.6.1.3 ATP + H2O + a kinesin associated with a microtubule at position n Homo sapiens
-
 ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
5.6.1.3 ATP + H2O + a kinesin associated with a microtubule at position n Xenopus laevis
-
 ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
5.6.1.3 ATP + H2O + a kinesin associated with a microtubule at position n Trypanosoma cruzi
-
 ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
5.6.1.3 GTP + H2O + a kinesin associated with a microtubule at position n Cricetulus griseus
-
 GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
5.6.1.3 GTP + H2O + a kinesin associated with a microtubule at position n Mus musculus
-
 GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
5.6.1.3 GTP + H2O + a kinesin associated with a microtubule at position n Homo sapiens
-
 GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
5.6.1.3 GTP + H2O + a kinesin associated with a microtubule at position n Xenopus laevis
-
 GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
5.6.1.3 GTP + H2O + a kinesin associated with a microtubule at position n Trypanosoma cruzi
-
 GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.3 Cricetulus griseus
-
 chinese hamster
-
5.6.1.3 Homo sapiens
-
-
-
5.6.1.3 Mus musculus
-
-
-
5.6.1.3 Trypanosoma cruzi
-
-
-
5.6.1.3 Xenopus laevis
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
5.6.1.3 ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (a) chains (110kDa) and two more light (b) chains (65-75 kDa). Also hydrolyzes GTP. Cricetulus griseus
a
5.6.1.3 ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (a) chains (110kDa) and two more light (b) chains (65-75 kDa). Also hydrolyzes GTP. Mus musculus
a
5.6.1.3 ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (a) chains (110kDa) and two more light (b) chains (65-75 kDa). Also hydrolyzes GTP. Homo sapiens
a
5.6.1.3 ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (a) chains (110kDa) and two more light (b) chains (65-75 kDa). Also hydrolyzes GTP. Xenopus laevis
a
5.6.1.3 ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (a) chains (110kDa) and two more light (b) chains (65-75 kDa). Also hydrolyzes GTP. Trypanosoma cruzi
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.1.3 embryo
-
 Mus musculus
-
5.6.1.3 fibroblast
-
 Mus musculus
-
5.6.1.3 fibroblast
-
 Homo sapiens
-
5.6.1.3 hippocampus
-
 Mus musculus
-
5.6.1.3 neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.3 ATP + H2O + a kinesin associated with a microtubule at position n
-
 Cricetulus griseus ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
5.6.1.3 ATP + H2O + a kinesin associated with a microtubule at position n
-
 Mus musculus ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
5.6.1.3 ATP + H2O + a kinesin associated with a microtubule at position n
-
 Homo sapiens ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
5.6.1.3 ATP + H2O + a kinesin associated with a microtubule at position n
-
 Xenopus laevis ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
5.6.1.3 ATP + H2O + a kinesin associated with a microtubule at position n
-
 Trypanosoma cruzi ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
5.6.1.3 GTP + H2O + a kinesin associated with a microtubule at position n
-
 Cricetulus griseus GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
5.6.1.3 GTP + H2O + a kinesin associated with a microtubule at position n
-
 Mus musculus GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
5.6.1.3 GTP + H2O + a kinesin associated with a microtubule at position n
-
 Homo sapiens GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
5.6.1.3 GTP + H2O + a kinesin associated with a microtubule at position n
-
 Xenopus laevis GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
5.6.1.3 GTP + H2O + a kinesin associated with a microtubule at position n
-
 Trypanosoma cruzi GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.1.3 CAK/KCM1
-
 Xenopus laevis
5.6.1.3 KIF1A
-
 Mus musculus
5.6.1.3 KIF1B
-
 Mus musculus
5.6.1.3 KIF2
-
 Mus musculus
5.6.1.3 KIF2beta
-
 Mus musculus
5.6.1.3 MCAK
-
 Cricetulus griseus
5.6.1.3 XKCM1
-
 Xenopus laevis
5.6.1.3 XKLP1
-
 Xenopus laevis