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Literature summary extracted from

  • Hartman, J.J.; Mahr, J.; McNally, K.; Okawa, K.; Iwamatsu, A.; Thomas, S.; Cheesman, S.; Heuser, J.; Vale, R.D.; McNally, F.J.
    Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit (1998), Cell, 93, 277-287.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.6.1.1 isolation of cDNA clones for the p60 and p80 subunits, heterologous expression of p60 in Sf9 cell baculovirus system Strongylocentrotus purpuratus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.6.1.1 centrosome
-
 Homo sapiens 5813
-
5.6.1.1 centrosome
-
 Xenopus laevis 5813
-
5.6.1.1 centrosome
-
 Strongylocentrotus purpuratus 5813
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.6.1.1 60000
-
 1 * 80000 + 1 * 60000, SDS-PAGE Strongylocentrotus purpuratus
5.6.1.1 80000
-
 1 * 80000 + 1 * 60000, SDS-PAGE Strongylocentrotus purpuratus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.1.1 ATP + H2O Drosophila sp. (in: flies)
-
 ADP + phosphate
-
 ?
5.6.1.1 ATP + H2O Homo sapiens
-
 ADP + phosphate
-
 ?
5.6.1.1 ATP + H2O Saccharomyces cerevisiae
-
 ADP + phosphate
-
 ?
5.6.1.1 ATP + H2O Xenopus laevis
-
 ADP + phosphate
-
 ?
5.6.1.1 ATP + H2O Caenorhabditis elegans
-
 ADP + phosphate
-
 ?
5.6.1.1 ATP + H2O Strongylocentrotus purpuratus
-
 ADP + phosphate
-
 ?
5.6.1.1 ATP + H2O Dictyostelium sp.
-
 ADP + phosphate
-
 ?
5.6.1.1 GTP + H2O Drosophila sp. (in: flies)
-
 GDP + phosphate
-
 ?
5.6.1.1 GTP + H2O Homo sapiens
-
 GDP + phosphate
-
 ?
5.6.1.1 GTP + H2O Saccharomyces cerevisiae
-
 GDP + phosphate
-
 ?
5.6.1.1 GTP + H2O Xenopus laevis
-
 GDP + phosphate
-
 ?
5.6.1.1 GTP + H2O Caenorhabditis elegans
-
 GDP + phosphate
-
 ?
5.6.1.1 GTP + H2O Strongylocentrotus purpuratus
-
 GDP + phosphate
-
 ?
5.6.1.1 GTP + H2O Dictyostelium sp.
-
 GDP + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.1 Caenorhabditis elegans
-
-
-
5.6.1.1 Dictyostelium sp.
-
-
-
5.6.1.1 Drosophila sp. (in: flies)
-
-
-
5.6.1.1 Homo sapiens
-
 human
-
5.6.1.1 Saccharomyces cerevisiae
-
-
-
5.6.1.1 Strongylocentrotus purpuratus
-
 sea urchin
-
5.6.1.1 Xenopus laevis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.6.1.1
-
 Strongylocentrotus purpuratus

Reaction

EC Number Reaction Comment Organism Reaction ID
5.6.1.1 n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome Drosophila sp. (in: flies)
a
5.6.1.1 n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome Homo sapiens
a
5.6.1.1 n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome Saccharomyces cerevisiae
a
5.6.1.1 n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome Xenopus laevis
a
5.6.1.1 n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome Caenorhabditis elegans
a
5.6.1.1 n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome Strongylocentrotus purpuratus
a
5.6.1.1 n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome Dictyostelium sp.
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.1.1 brain
-
 Homo sapiens
-
5.6.1.1 egg
-
 Xenopus laevis
-
5.6.1.1 egg
-
 Strongylocentrotus purpuratus
-
5.6.1.1 embryo
-
 Strongylocentrotus purpuratus
-
5.6.1.1 fibroblast
-
 Homo sapiens
-
5.6.1.1 hippocampus
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.1 ATP + H2O
-
 Drosophila sp. (in: flies) ADP + phosphate
-
 ?
5.6.1.1 ATP + H2O
-
 Homo sapiens ADP + phosphate
-
 ?
5.6.1.1 ATP + H2O
-
 Saccharomyces cerevisiae ADP + phosphate
-
 ?
5.6.1.1 ATP + H2O
-
 Xenopus laevis ADP + phosphate
-
 ?
5.6.1.1 ATP + H2O
-
 Caenorhabditis elegans ADP + phosphate
-
 ?
5.6.1.1 ATP + H2O
-
 Strongylocentrotus purpuratus ADP + phosphate
-
 ?
5.6.1.1 ATP + H2O
-
 Dictyostelium sp. ADP + phosphate
-
 ?
5.6.1.1 GTP + H2O
-
 Drosophila sp. (in: flies) GDP + phosphate
-
 ?
5.6.1.1 GTP + H2O
-
 Homo sapiens GDP + phosphate
-
 ?
5.6.1.1 GTP + H2O
-
 Saccharomyces cerevisiae GDP + phosphate
-
 ?
5.6.1.1 GTP + H2O
-
 Xenopus laevis GDP + phosphate
-
 ?
5.6.1.1 GTP + H2O
-
 Caenorhabditis elegans GDP + phosphate
-
 ?
5.6.1.1 GTP + H2O
-
 Strongylocentrotus purpuratus GDP + phosphate
-
 ?
5.6.1.1 GTP + H2O
-
 Dictyostelium sp. GDP + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
5.6.1.1 dimer
-
 Xenopus laevis
5.6.1.1 dimer
-
 Caenorhabditis elegans
5.6.1.1 dimer 1 * 80000 + 1 * 60000, SDS-PAGE Strongylocentrotus purpuratus

Synonyms

EC Number Synonyms Comment Organism
5.6.1.1 mei-1
-
 Caenorhabditis elegans
5.6.1.1 Sug1p
-
 Saccharomyces cerevisiae

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5.6.1.1 0.005
-
 ATP p60/p80 heterodimer Strongylocentrotus purpuratus