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Literature summary extracted from

  • Brodsky, J.L.
    Selectivity of the molecular chaperone-specific immunosuppressive agent 15-deoxyspergualin. Modulation of Hsc70 ATPase activity without compromising DnaJ chaperone interactions (1999), Biochem. Pharmacol., 57, 877-880.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.6.4.10 15-deoxyspergualin stimulates the ATPase activity of mammalian and yeast cytosolic Hsc70 from 20 to 40%, no effect on HSC70 BiP and DnaJ-stimulated Hsc70 ATPase activity Saccharomyces cerevisiae
3.6.4.10 15-deoxyspergualin stimulates the ATPase activity of mammalian and yeast cytosolic Hsc70 from 20 to 40%, no effect on HSC70 BiP and DnaJ-stimulated Hsc70 ATPase activity Bos taurus
3.6.4.10 DnaJ
-
Rattus norvegicus
3.6.4.10 DnaJ
-
Saccharomyces cerevisiae
3.6.4.10 DnaJ
-
Bos taurus

Application

EC Number Application Comment Organism
3.6.4.10 medicine development of a potent cytostatic anti-tumor and immunosuppressive agent, 15-deoxyspergualin, a synthetic analogue of the antibiotic spergualin, to prevent rejection in kidney transplant recipients Saccharomyces cerevisiae
3.6.4.10 medicine development of a potent cytostatic anti-tumor and immunosuppressive agent, 15-deoxyspergualin, a synthetic analogue of the antibiotic spergualin, to prevent rejection in kidney transplant recipients Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.4.10 cytosol
-
Saccharomyces cerevisiae 5829
-
3.6.4.10 cytosol
-
Bos taurus 5829
-
3.6.4.10 endoplasmic reticulum
-
Saccharomyces cerevisiae 5783
-
3.6.4.10 endoplasmic reticulum
-
Bos taurus 5783
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.6.4.10 70000
-
gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.4.10 ATP + H2O Rattus norvegicus
-
ADP + phosphate
-
?
3.6.4.10 ATP + H2O Saccharomyces cerevisiae
-
ADP + phosphate
-
?
3.6.4.10 ATP + H2O Bos taurus
-
ADP + phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.6.4.10 Bos taurus
-
-
-
3.6.4.10 Rattus norvegicus
-
rat
-
3.6.4.10 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.4.10
-
Bos taurus

Reaction

EC Number Reaction Comment Organism Reaction ID
3.6.4.10 ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Rattus norvegicus
3.6.4.10 ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Saccharomyces cerevisiae
3.6.4.10 ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.4.10 ATP + H2O
-
Rattus norvegicus ADP + phosphate
-
?
3.6.4.10 ATP + H2O
-
Saccharomyces cerevisiae ADP + phosphate
-
?
3.6.4.10 ATP + H2O
-
Bos taurus ADP + phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.6.4.10 eukaryotic Hsc70 ATPase
-
Saccharomyces cerevisiae
3.6.4.10 eukaryotic Hsc70 ATPase
-
Bos taurus