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Literature summary extracted from

  • Blond-Elguindi, S.; Fourie, A.M.; Sambrook, J.F.; Gething, M.J.H.
    Peptide-dependent stimulation of the ATPase activity of the molecular chaperone BiP is the result of conversion of oligomers to active monomers (1993), J. Biol. Chem., 268, 12730-12735.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.4.10 pT7-mBiP containing the cDNA sequence encoding mature mouse BiP cloned and expressed in Escherichia coli BL21 Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.4.10 0.0004
-
 ATP
-
 Mus musculus
3.6.4.10 0.67
-
 ATP
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.4.10 cytosol hsc70 Bos taurus 5829
-
3.6.4.10 endoplasmic reticulum Hsp70 Bos taurus 5783
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.6.4.10 30000
-
 1 * 44000 + 1 * 30000 Bos taurus
3.6.4.10 44000
-
 1 * 44000 + 1 * 30000 Bos taurus
3.6.4.10 70000
-
-
 Bos taurus
3.6.4.10 78000
-
 grp78/BiP Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.4.10 ATP + H2O Cricetulus griseus
-
 ADP + phosphate
-
 ?
3.6.4.10 ATP + H2O Mus musculus
-
 ADP + phosphate
-
 ?
3.6.4.10 ATP + H2O Bos taurus
-
 ADP + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.4.10 Bos taurus
-
-
-
3.6.4.10 Cricetulus griseus
-
 chinese hamster
-
3.6.4.10 Mus musculus
-
 mouse
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.4.10
-
 Bos taurus
3.6.4.10 recombinant murine BiP, expressed in Escherichia coli Mus musculus

Reaction

EC Number Reaction Comment Organism Reaction ID
3.6.4.10 ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Cricetulus griseus
a
3.6.4.10 ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Mus musculus
a
3.6.4.10 ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.4.10 liver
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.4.10 ATP + H2O
-
 Cricetulus griseus ADP + phosphate
-
 ?
3.6.4.10 ATP + H2O
-
 Mus musculus ADP + phosphate
-
 ?
3.6.4.10 ATP + H2O
-
 Bos taurus ADP + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.6.4.10 dimer 1 * 44000 + 1 * 30000 Bos taurus

Synonyms

EC Number Synonyms Comment Organism
3.6.4.10 BiP
-
 Cricetulus griseus
3.6.4.10 BiP
-
 Bos taurus
3.6.4.10 Grp78
-
 Cricetulus griseus
3.6.4.10 Grp78
-
 Bos taurus
3.6.4.10 Hsp70
-
 Bos taurus
3.6.4.10 molecular chaperone BiP
-
 Bos taurus