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Literature summary extracted from
- The Ca2+-pumping ATPase of plasma membranes. Purification, reconstitution and properties (1982), Biochim. Biophys. Acta, 683, 279-301.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.10 | Calmodulin | shifts the Ca2+-ATPase to the high-affinity form | Homo sapiens |  |
| 7.2.2.10 | additional information | activation by controlled proteolysis | Homo sapiens | |
| 7.2.2.10 | phosphatidylserine | can replace calmodulin in shifting the enzyme to the high-affinity form | Homo sapiens | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.10 | 4,4'-diisothiocyano-2,2'-stilbenedisulfonic acid | - |
Homo sapiens | |
| 7.2.2.10 | N-4-(azido-2-nitrophenyl)-2-aminoethylsulfonate | - |
Homo sapiens | |
| 7.2.2.10 | vanadate | - |
Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 7.2.2.10 | 0.000013 | - |
Ca2+ | enzyme from liver | Homo sapiens | |
| 7.2.2.10 | 0.000021 | - |
ATP | enzyme from liver | Homo sapiens | |
| 7.2.2.10 | 0.000037 | - |
UTP | enzyme from liver | Homo sapiens | |
| 7.2.2.10 | 0.0005 | - |
Ca2+ | phosphatidylserine environment with or without calmodulin, enzyme from erythrocytes | Homo sapiens | |
| 7.2.2.10 | 0.02 | - |
Ca2+ | phosphatidylcholine environment with or without calmodulin, enzyme from erythrocytes | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.2.2.10 | membrane | - |
Homo sapiens | 16020 | - |
| 7.2.2.10 | plasma membrane | - |
Homo sapiens | 5886 | - |
| 7.2.2.10 | sarcoplasmic reticulum | - |
Homo sapiens | 16529 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 7.2.2.10 | 138000 | - |
x * 138000, enzyme may exist in both the monomeric and dimeric enzyme form, SDS-PAGE | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.2.2.10 | Homo sapiens | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 7.2.2.10 | no glycoprotein | - |
Homo sapiens |
| 7.2.2.10 | side-chain modification | contains about 7 mol phosphate per mol of protein | Homo sapiens |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 7.2.2.10 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 7.2.2.10 | erythrocyte | - |
Homo sapiens | - |
| 7.2.2.10 | liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.2.10 | ATP + H2O + Ca2+/out | - |
Homo sapiens | ADP + phosphate + Ca2+/in | - |
? | |
| 7.2.2.10 | UTP + H2O + Ca2+/in | - |
Homo sapiens | UDP + phosphate + Ca2+/out | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 7.2.2.10 | ? | x * 138000, enzyme may exist in both the monomeric and dimeric enzyme form, SDS-PAGE | Homo sapiens |
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