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Literature summary extracted from

  • Van Kuijck, M.A.; van Aubel, R.A.M.H.; Busch, A.E.; Lang, F.; Russell, F.G.M.; Bindels, R.J.M.; van Os, C.H.; Deen, P.M.T.
    Molecular cloning and expression of a cyclic AMP-activated chloride conductance regulator: a novel ATP binding cassette transporter (1996), Proc. Natl. Acad. Sci. USA, 93, 5401-5406.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.6.1.6 cAMP activates Homo sapiens
5.6.1.6 cAMP activates Oryctolagus cuniculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.6.1.6 expression in Xenopus oocytes Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.1.6 5-nitro-2-(3-phenylpropylamine)benzoic acid
-
 Oryctolagus cuniculus
5.6.1.6 niflumic acid
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.1.6 ATP + H2O + closed Cl- channel Homo sapiens
-
 ADP + phosphate + open Cl- channel
-
 ?
5.6.1.6 ATP + H2O + closed Cl- channel Oryctolagus cuniculus EBCR is involved in hormone-regulated chloride reabsorption ADP + phosphate + open Cl- channel
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.6 Homo sapiens
-
-
-
5.6.1.6 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.1.6 epithelium
-
 Homo sapiens
-
5.6.1.6 epithelium
-
 Oryctolagus cuniculus
-
5.6.1.6 kidney basolateral localization mainly in the thick ascending limb of Henleย‘s loop, distal convoluted tubules and to a lesser extent connecting tubules Oryctolagus cuniculus
-
5.6.1.6 liver
-
 Oryctolagus cuniculus
-
5.6.1.6 small intestine
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.6 ATP + H2O + closed Cl- channel
-
 Homo sapiens ADP + phosphate + open Cl- channel
-
 ?
5.6.1.6 ATP + H2O + closed Cl- channel chloride channel Homo sapiens ADP + phosphate + open Cl- channel
-
 ?
5.6.1.6 ATP + H2O + closed Cl- channel chloride channel Oryctolagus cuniculus ADP + phosphate + open Cl- channel
-
 ?
5.6.1.6 ATP + H2O + closed Cl- channel EBCR is involved in hormone-regulated chloride reabsorption Oryctolagus cuniculus ADP + phosphate + open Cl- channel
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.1.6 EBCR
-
 Oryctolagus cuniculus
5.6.1.6 epithelial basolateral chloride conductance regulator
-
 Oryctolagus cuniculus