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Literature summary extracted from

  • Bear, C.E.; Li, C.; Galley, K.; Wang, Y.; Garami, E.; Ramjeesingh, M.
    Coupling of ATP hydrolysis with channel gating by purified, reconstituted CFTR (1997), J. Bioenerg. Biomembr., 29, 465-473.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
5.6.1.6 additional information the mutant enzyme CFTRG551D, associated with human disease, exhibits defective ATPase activity Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.6.1.6 0.1
-
 ATP
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.6.1.6 membrane apical membrane of epithelia Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.1.6 ATP + H2O + closed Cl- channel Homo sapiens coupling between ATP hydrolysis and chloride channel gating ADP + phosphate + open Cl- channel
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.6 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.1.6 epithelium apical membrane of epithelia Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.6 ATP + H2O + closed Cl- channel chloride channel Homo sapiens ADP + phosphate + open Cl- channel
-
 ?
5.6.1.6 ATP + H2O + closed Cl- channel coupling between ATP hydrolysis and chloride channel gating Homo sapiens ADP + phosphate + open Cl- channel
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5.6.1.6 additional information
-
 additional information 60-120 gating events per min Homo sapiens
5.6.1.6 0.22
-
 ATP
-
 Homo sapiens