Literature summary extracted from

Schwiebert, E.M.; Benos, D.J.; Egan, M.E.; Stutts, M.J.; Guggino, W.B.
CFTR is a conductance regulator as well as a chloride channel (1999), Physiol. Rev., 79, S145-166.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5.6.1.6	ATP + H2O + closed Cl- channel	Homo sapiens	CFTR is a conductance regulator as well as a Cl- channel, CFTR regulates other ion channel proteins	ADP + phosphate + open Cl- channel	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
5.6.1.6	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5.6.1.6	ATP + H2O + closed Cl- channel	chloride channel	Homo sapiens	ADP + phosphate + open Cl- channel	-	?
5.6.1.6	ATP + H2O + closed Cl- channel	dysfunction of CFTR causes the genetic disease cystic fibrosis	Homo sapiens	ADP + phosphate + open Cl- channel	-	?
5.6.1.6	ATP + H2O + closed Cl- channel	CFTR is a conductance regulator as well as a Cl- channel, CFTR regulates other ion channel proteins	Homo sapiens	ADP + phosphate + open Cl- channel	-	?

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Release 2023.1 (January 2023)