Literature summary extracted from

Paul, S.; Breuninger, L.M.; Tew, K.D.; Shen, H.; Kruh, G.D.
ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles estabilshes MRP as a broad specificity transporter (1996), Proc. Natl. Acad. Sci. USA, 93, 6929-6934.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
7.6.2.2	arsenate	competitive	Mus musculus
7.6.2.2	GSH	competitive	Mus musculus
7.6.2.2	GSSG	competitive	Mus musculus
7.6.2.2	leukotriene D4	competitive	Mus musculus
7.6.2.2	MK571	competitive	Mus musculus
7.6.2.2	S-(2,4-dinitrophenyl)glutathione	competitive	Mus musculus
7.6.2.2	S-(p-azidophenylacyl)-glutathione	competitive	Mus musculus

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
7.6.2.2	0.000035	-	leukotriene C4/in	-	Mus musculus
7.6.2.2	0.0042	-	vincristine/in	-	Mus musculus
7.6.2.2	0.0044	-	etoposide/in	-	Mus musculus
7.6.2.2	0.0063	-	daunorubicin/in	-	Mus musculus
7.6.2.2	0.038	-	ATP	-	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
7.6.2.2	Mus musculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
7.6.2.2	NIH-3T3 cell	NIH 3T3 MRP transfectant pSRalpha-MRP-32 cells	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
7.6.2.2	daunorubicin/in + ATP + H2O	-	Mus musculus	daunorubicin/out + ADP + phosphate	-	?
7.6.2.2	etoposide/in + ATP + H2O	-	Mus musculus	etoposide/out + ADP + phosphate	-	?
7.6.2.2	leukotriene C4/in + ATP + H2O	-	Mus musculus	leukotriene C4/out + ADP + phosphate	-	?
7.6.2.2	taxol/in + ATP + H2O	weak activity	Mus musculus	taxol/out + ADP + H2O	-	?
7.6.2.2	vinblastine/in + ATP + H2O	weak activity	Mus musculus	vinblastine/out + ADP + phosphate	-	?
7.6.2.2	vincristine/in + ATP + H2O	-	Mus musculus	vincristine/out + ADP + phosphate	-	?

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Release 2023.1 (January 2023)