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Literature summary extracted from

  • Loe, D.W.; Deeley, R.G.; Cole, S.P.C.
    Characterization of vincristine transport by the Mr 190000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione (1998), Cancer Res., 58, 5130-5136.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.6.2.2 GSH stimulates transport of vincristine Homo sapiens
7.6.2.2 L-gamma-glutamyl-S-methyl-L-cysteinylglycine supports transport of vincristine Homo sapiens
7.6.2.2 S-butyl-GSH supports transport of vincristine Homo sapiens
7.6.2.2 S-ethyl-GSH supports transport of vincristine Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.6.2.2 GSH alone is a very poor inhibitor of transport of leukotriene C4, together with vincristine acts as relatively potent competitive inhibitor Homo sapiens
7.6.2.2 vincristine alone is a very poor inhibitor of transport of leukotriene C4, together with GSH acts as relatively potent competitive inhibitor Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.2 membrane
-
 Homo sapiens 16020
-

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.2 H69 cell
-
 Homo sapiens
-
7.6.2.2 RPMI-8226 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.2 leukotriene C4/in + ATP + H2O
-
 Homo sapiens leukotriene C4/out + ADP + phosphate
-
 ?
7.6.2.2 vincristine/in + ATP + H2O
-
 Homo sapiens vincristine/out + ADP + phosphate cotransport with reduced glutathione ?