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Literature summary extracted from

  • Cole, S.P.C.; Deeley, R.G.
    Multidrug resistance mediated by the ATP-binding cassette transporter protein MRP (1998), Bioessays, 20, 931-940.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.6.2.2 GSH transport of unconjugated chemotherapeutic agents requires cotransport of glutathione, GSH by itself is not a substrate Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.2 membrane
-
 Mus musculus 16020
-
7.6.2.2 membrane contains an additional third NH2-proximal membrane-spanning domain, not found in previously characterized ABC transporters. This domain, whose NH2-terminus is extracytolsolic, is essential for MRP-mediated transport activity Homo sapiens 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
7.6.2.2 190000
-
 1 * 190000, MRP from lung cancer cell line, calculation from nucleotide sequence Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.2 additional information Mus musculus
-
 ?
-
 ?
7.6.2.2 additional information Homo sapiens the physiological function can range from a protective role in chemical toxicity and oxidative stress to mediation of inflammatory responses involving cysteinyl leukotrienes ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.2 Homo sapiens
-
-
-
7.6.2.2 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.2 lung cancer cell line
-
 Homo sapiens
-
7.6.2.2 RPMI-8226 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.2 aflatoxin B1/in + ATP + H2O
-
 Homo sapiens aflatoxin B1/out + ADP + phosphate
-
 ?
7.6.2.2 cysteinyl leukotriene C4/in + ATP + H2O
-
 Homo sapiens cysteinyl leukotriene C4/out + ADP + phosphate
-
 ?
7.6.2.2 estradiol 17-beta-D-glucuronide/in + ATP + H2O
-
 Homo sapiens estradiol 17-beta-D-glucuronide/out + ADP + phosphate
-
 ?
7.6.2.2 additional information
-
 Mus musculus ?
-
 ?
7.6.2.2 additional information the physiological function can range from a protective role in chemical toxicity and oxidative stress to mediation of inflammatory responses involving cysteinyl leukotrienes Homo sapiens ?
-
 ?
7.6.2.2 vincristine/in + ATP + H2O
-
 Mus musculus vincristine/out + ADP + phosphate
-
 ?
7.6.2.2 vincristine/in + ATP + H2O requires cotransport of GSH Homo sapiens vincristine/out + ADP + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
7.6.2.2 ? 1 * 190000, MRP from lung cancer cell line, calculation from nucleotide sequence Homo sapiens