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Literature summary extracted from

  • Sharom, F.J.; Liu, R.; Romsicki, Y.; Lu, P.
    Insight into the structure and substrate interactions of the P-glycoprotein multidrug transporter from spectroscopic studies (1999), Biochim. Biophys. Acta, 1461, 327-345.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.6.2.2 2-(4-maleimidoanilino)-naphthalene-6-sulfonic acid
-
 Homo sapiens
7.6.2.2 cyclosporin A
-
 Homo sapiens
7.6.2.2 flavonoids useful inhibitors for clinical application to multidrug resistance Homo sapiens
7.6.2.2 quercetin
-
 Homo sapiens
7.6.2.2 verapamil
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.2 plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.2 additional information Mus musculus
-
 ?
-
 ?
7.6.2.2 additional information Rattus norvegicus
-
 ?
-
 ?
7.6.2.2 additional information Homo sapiens exports a diverse group of natural products chemotherapeutic drugs, and hydrophobic peptides across the plasma membrane ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.2 Homo sapiens
-
-
-
7.6.2.2 Mus musculus
-
-
-
7.6.2.2 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
7.6.2.2 glycoprotein glycosylation is not essential for ATPase or transport function, the N-linked oligosaccharides appear to influence the conformation of the protein in a subtle way Mus musculus
7.6.2.2 glycoprotein glycosylation is not essential for ATPase or transport function, the N-linked oligosaccharides appear to influence the conformation of the protein in a subtle way Homo sapiens
7.6.2.2 glycoprotein glycosylation is not essential for ATPase or transport function, the N-linked oligosaccharides appear to influence the conformation of the protein in a subtle way Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.2 RPMI-8226 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.2 additional information
-
 Mus musculus ?
-
 ?
7.6.2.2 additional information
-
 Rattus norvegicus ?
-
 ?
7.6.2.2 additional information the enzyme operates in an alternating sites mechanism, that is when one catalytic site enters the transition state, the other is unable to do so Homo sapiens ?
-
 ?
7.6.2.2 additional information exports a diverse group of natural products chemotherapeutic drugs, and hydrophobic peptides across the plasma membrane Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
7.6.2.2 More enzyme contains a membrane-associated domain made up of 12 alpha-helical membrane-spanning segments and two highly conserved cytosolic nucleotide-binding domains which couple ATP hydrolysis to substrate import or export Homo sapiens