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Literature summary extracted from

  • Kakinuma, Y.; Yamato, I.; Murata, T.
    Structure and function of vacuolar Na+-translocating ATPase in Enterococcus hirae (1999), J. Bioenerg. Biomembr., 31, 7-14.
    View publication on PubMed

Application

EC Number Application Comment Organism
7.2.2.3 medicine ATP synthesis, Na+ pump Enterococcus hirae

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.2.2.3
-
 Enterococcus hirae

Protein Variants

EC Number Protein Variants Comment Organism
7.2.2.1 A236C mutant of NtpA subunit with higher sensitivity for NEM Enterococcus hirae

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.1 destruxin B
-
 Enterococcus hirae
7.2.2.1 NEM
-
 Enterococcus hirae
7.2.2.3 destruxin B
-
 Enterococcus hirae
7.2.2.3 Dicyclohexylcarbodiimide
-
 Enterococcus hirae
7.2.2.3 EDTA
-
 Enterococcus hirae
7.2.2.3 N-ethylmaleimide
-
 Enterococcus hirae
7.2.2.3 valinomycin
-
 Enterococcus hirae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.1 membrane
-
 Enterococcus hirae 16020
-
7.2.2.3 plasma membrane
-
 Enterococcus hirae 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.2.2.1 Li+ ATP hydrolytic activity absolutely requires Na+ or Li+ Enterococcus hirae
7.2.2.1 Li+ translocation of Li+ Enterococcus hirae
7.2.2.1 Na+ the enzyme has Na+-translocating activity Enterococcus hirae
7.2.2.1 Na+ ATP hydrolytic activity absolutely requires Na+ or Li+ Enterococcus hirae
7.2.2.3 Li+
-
 Enterococcus hirae
7.2.2.3 Mg2+
-
 Enterococcus hirae
7.2.2.3 Na+
-
 Enterococcus hirae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
7.2.2.1 11000
-
 x * 66000, subunitA, + x * 51000, subunit B, + x * 76000, subunit I, + x * 38000, subunit C, + x * 27000, subunit D, + x * 23000, subunit E, + x * 16000, subunit K, + x * 14000, subunit F, + x * 11000, subunit G Enterococcus hirae
7.2.2.1 14000
-
 x * 66000, subunitA, + x * 51000, subunit B, + x * 76000, subunit I, + x * 38000, subunit C, + x * 27000, subunit D, + x * 23000, subunit E, + x * 16000, subunit K, + x * 14000, subunit F, + x * 11000, subunit G Enterococcus hirae
7.2.2.1 16000
-
 x * 66000, subunitA, + x * 51000, subunit B, + x * 76000, subunit I, + x * 38000, subunit C, + x * 27000, subunit D, + x * 23000, subunit E, + x * 16000, subunit K, + x * 14000, subunit F, + x * 11000, subunit G Enterococcus hirae
7.2.2.1 23000
-
 x * 66000, subunitA, + x * 51000, subunit B, + x * 76000, subunit I, + x * 38000, subunit C, + x * 27000, subunit D, + x * 23000, subunit E, + x * 16000, subunit K, + x * 14000, subunit F, + x * 11000, subunit G Enterococcus hirae
7.2.2.1 27000
-
 x * 66000, subunitA, + x * 51000, subunit B, + x * 76000, subunit I, + x * 38000, subunit C, + x * 27000, subunit D, + x * 23000, subunit E, + x * 16000, subunit K, + x * 14000, subunit F, + x * 11000, subunit G Enterococcus hirae
7.2.2.1 38000
-
 x * 66000, subunitA, + x * 51000, subunit B, + x * 76000, subunit I, + x * 38000, subunit C, + x * 27000, subunit D, + x * 23000, subunit E, + x * 16000, subunit K, + x * 14000, subunit F, + x * 11000, subunit G Enterococcus hirae
7.2.2.1 51000
-
 x * 66000, subunitA, + x * 51000, subunit B, + x * 76000, subunit I, + x * 38000, subunit C, + x * 27000, subunit D, + x * 23000, subunit E, + x * 16000, subunit K, + x * 14000, subunit F, + x * 11000, subunit G Enterococcus hirae
7.2.2.1 66000
-
 x * 66000, subunitA, + x * 51000, subunit B, + x * 76000, subunit I, + x * 38000, subunit C, + x * 27000, subunit D, + x * 23000, subunit E, + x * 16000, subunit K, + x * 14000, subunit F, + x * 11000, subunit G Enterococcus hirae
7.2.2.1 76000
-
 x * 66000, subunitA, + x * 51000, subunit B, + x * 76000, subunit I, + x * 38000, subunit C, + x * 27000, subunit D, + x * 23000, subunit E, + x * 16000, subunit K, + x * 14000, subunit F, + x * 11000, subunit G Enterococcus hirae
7.2.2.3 29000
-
 3 * 65000 + 3 * 56000 + 1 * 29000 Enterococcus hirae
7.2.2.3 56000
-
 3 * 65000 + 3 * 56000 + 1 * 29000 Enterococcus hirae
7.2.2.3 65000
-
 3 * 65000 + 3 * 56000 + 1 * 29000 Enterococcus hirae
7.2.2.3 400000
-
-
 Enterococcus hirae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.1 additional information Enterococcus hirae enzyme is induced when cells are grown on media rich in sodium ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.1 Enterococcus hirae
-
-
-
7.2.2.3 Enterococcus hirae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
7.2.2.1
-
 Enterococcus hirae
7.2.2.3
-
 Enterococcus hirae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.1 ATP + H2O translocation of Li+ Enterococcus hirae ADP + phosphate
-
 ?
7.2.2.1 additional information enzyme is induced when cells are grown on media rich in sodium Enterococcus hirae ?
-
 ?

Subunits

EC Number Subunits Comment Organism
7.2.2.1 ? x * 66000, subunitA, + x * 51000, subunit B, + x * 76000, subunit I, + x * 38000, subunit C, + x * 27000, subunit D, + x * 23000, subunit E, + x * 16000, subunit K, + x * 14000, subunit F, + x * 11000, subunit G Enterococcus hirae
7.2.2.3 nonamer
-
 Enterococcus hirae
7.2.2.3 oligomer 3 * 65000 + 3 * 56000 + 1 * 29000 Enterococcus hirae

Synonyms

EC Number Synonyms Comment Organism
7.2.2.1 V-ATPase
-
 Enterococcus hirae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2.2.1 8.6 9
-
 Enterococcus hirae
7.2.2.3 8.5 9
-
 Enterococcus hirae