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Literature summary extracted from
- Na+ binding of V-type Na+-ATPase in Enterococcus hirae (2000), J. Biol. Chem., 275, 13415-13419.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 7.2.2.3 | medicine | ATP synthesis, Na+ pump | Enterococcus hirae |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.1 | ATPgammaS | inhibits ATPase activity but not the Na+ binding capacity of the enzyme | Enterococcus hirae |  |
| 7.2.2.3 | ATPgammaS | - |
Enterococcus hirae | |
| 7.2.2.3 | destruxin B | - |
Enterococcus hirae | |
| 7.2.2.3 | Dicyclohexylcarbodiimide | - |
Enterococcus hirae | |
| 7.2.2.3 | nitrate | - |
Enterococcus hirae | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.1 | Na+ | the enzyme has Na+-translocating activity | Enterococcus hirae | |
| 7.2.2.1 | Na+ | 6 Na+ are bound per enzyme molecule by a singly high affinity, about two-thirds of the Na+ binding sites of the Na+ ATPase are readily acessible from the aqueous phase | Enterococcus hirae | |
| 7.2.2.3 | Na+ | - |
Enterococcus hirae | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.2.3 | ATP + H2O + Na+/in | Enterococcus hirae | - |
ADP + phosphate + Na+/out | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.2.2.1 | Enterococcus hirae | - |
- |
- |
| 7.2.2.3 | Enterococcus hirae | - |
strain ATCC 9790 | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 7.2.2.3 | - |
Enterococcus hirae |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 7.2.2.3 | 26 | - |
- |
Enterococcus hirae |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.2.1 | ATP + H2O | - |
Enterococcus hirae | ADP + phosphate | - |
? | |
| 7.2.2.3 | ATP + H2O + Na+/in | - |
Enterococcus hirae | ADP + phosphate + Na+/out | - |
r | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.2.2.1 | V-ATPase | - |
Enterococcus hirae |
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