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Literature summary extracted from
- Role of thiamine metabolism in the central nervous system. I. Basic properties of thiamine triphosphatase in rat brain (1974), Jpn. J. Pharmacol., 24, 817-823.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.6.1.28 | Ca2+ | physiological concentrations markedly inhibit soluble TTPase | Rattus norvegicus |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.6.1.28 | membrane | - |
Rattus norvegicus | 16020 | - |
| 3.6.1.28 | microsome | - |
Rattus norvegicus | - |
- |
| 3.6.1.28 | soluble | - |
Rattus norvegicus | - |
- |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.6.1.28 | Ca2+ | divalent cation requirement is fullfilled by Mg2+ or Ca2+ in microsomes and by Mg2+ but not Ca2+ in soluble fraction | Rattus norvegicus | |
| 3.6.1.28 | Mg2+ | divalent cation requirement is fullfilled by Mg2+ or Ca2+ in microsomes and by Mg2+ but not Ca2+ in soluble fraction | Rattus norvegicus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.6.1.28 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.6.1.28 | brain | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.1.28 | ATP + H2O | 4% of the activity with thiamine triphosphate | Rattus norvegicus | ADP + phosphate | - |
? | |
| 3.6.1.28 | GTP + H2O | at 13% of the activity with thiamine triphosphate | Rattus norvegicus | GDP + phosphate | - |
? | |
| 3.6.1.28 | thiamine triphosphate + H2O | - |
Rattus norvegicus | thiamine diphosphate + phosphate | - |
? | |
| 3.6.1.28 | UTP + H2O | no activity | Rattus norvegicus | UDP + phosphate | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.6.1.28 | 6.5 | - |
and a second optimum at pH 7.8, microsomal enzyme | Rattus norvegicus |
| 3.6.1.28 | 7.8 | - |
and a second optimum at pH 6.5, microsomal enzyme | Rattus norvegicus |
| 3.6.1.28 | 8.5 | 9 | soluble enzyme | Rattus norvegicus |
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Release 2023.1 (January 2023)
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