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Literature summary extracted from

  • Hashitani, Y.; Cooper, J.R.
    The partial purification of thiamine triphosphatase from rat brain (1972), J. Biol. Chem., 247, 2117-2119.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.28 Ca2+ 0.2 mM CaCl2, 50% inhibition Rattus norvegicus
3.6.1.28 F- 5 mM, 55% inhibition Rattus norvegicus
3.6.1.28 thiamine diphosphate 0.75 mM, 55% inhibition Rattus norvegicus
3.6.1.28 thiamine phosphate 0.75 mM, 12% inhibition Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.1.28 1.2
-
 thiamine triphosphate
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.1.28 soluble
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.28 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.28 brain
-
 Rattus norvegicus
-
3.6.1.28 heart
-
 Rattus norvegicus
-
3.6.1.28 intestine
-
 Rattus norvegicus
-
3.6.1.28 kidney
-
 Rattus norvegicus
-
3.6.1.28 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.6.1.28 1.69
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.28 CTP + H2O at 13% of the activity with thiamine triphosphate Rattus norvegicus CDP + phosphate
-
 ?
3.6.1.28 GTP + H2O at 4% of the activity with thiamine triphosphate Rattus norvegicus GDP + phosphate
-
 ?
3.6.1.28 thiamine triphosphate + H2O
-
 Rattus norvegicus thiamine diphosphate + phosphate
-
 ?
3.6.1.28 UTP + H2O at 2% of the activity with thiamine triphosphate Rattus norvegicus UDP + phosphate
-
 ?