BRENDA - Enzyme Database

Stereospecific synthesis and enzyme studies of CDP-diacylglycerols

Murthy, P.P.N.; Agranoff, B.W.; Biochim. Biophys. Acta 712, 473-483 (1982)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.6.1.26
Triton X-100
detergent required for activity, optimum concentration 0.3%
Cavia porcellus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.8.11
AMP
non-competitive inhibition
Cavia porcellus
3.6.1.26
AMP
none competitive, Ki: 0.04 mM
Cavia porcellus
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.7.8.11
0.03
-
CDP-1-stearoyl-2-oleoylglycerol
pH 8.3, 37°C
Cavia porcellus
2.7.8.11
0.045
-
1-stearoyl-2-arachidonoylglycerol
pH 8.3, 37°C
Cavia porcellus
2.7.8.11
0.05
-
dipalmitoyl-sn-glycerol
pH 8.3, 37°C
Cavia porcellus
2.7.8.11
0.16
-
CDP-distearoylglycerol
pH 8.3, 37°C
Cavia porcellus
3.6.1.26
0.04
-
CDP-1-stearoyl-2-oleoylglycerol
-
Cavia porcellus
3.6.1.26
0.047
-
CDP-1-stearoyl-2-stearoylglycerol
-
Cavia porcellus
3.6.1.26
0.063
-
CDPdipalmitoylglycerol
-
Cavia porcellus
3.6.1.26
0.14
-
CDPdistearoylglycerol
-
Cavia porcellus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.6.1.26
lysosome
-
Cavia porcellus
5764
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.8.11
CDP-diacylglycerol + myo-inositol
Cavia porcellus
-
CMP + phosphatidyl-1D-myo-inositol
-
Cavia porcellus
r
3.6.1.26
CDPdiacylglycerol + H2O
Cavia porcellus
-
CMP + phosphatidate
-
Cavia porcellus
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.8.11
Cavia porcellus
-
guinea pig
-
3.6.1.26
Cavia porcellus
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
3.6.1.26
-
Cavia porcellus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.8.11
brain
-
Cavia porcellus
-
3.6.1.26
brain
-
Cavia porcellus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.8.11
CDP-1-arachidonoyl-2-stearoylglycerol + myo-inositol
6% of the activity with CDP-1-stearoyl-2-oleoylglycerol
210005
Cavia porcellus
CMP + 1-arachidonoyl-2-stearoylphosphtidylinositol
-
-
-
r
2.7.8.11
CDP-1-stearoyl-2-arachidonoylglycerol + myo-inositol
4% of the activity with CDP-1-stearoyl-2-oleoylglycerol
210005
Cavia porcellus
CMP + 1-stearoyl-2-arachidonoylphosphatidylinositol
-
-
-
r
2.7.8.11
CDP-1-stearoyl-2-oleoylglycerol + myo-inositol
-
210005
Cavia porcellus
CMP + 1-stearoyl-2-oleoylphosphatidylinositol
-
-
-
r
2.7.8.11
CDP-diacylglycerol + myo-inositol
-
210005
Cavia porcellus
CMP + phosphatidyl-1D-myo-inositol
-
210005
Cavia porcellus
r
2.7.8.11
CDP-diarachidonoylglycerol + myo-inositol
9% of the activity with CDP-1-stearoyl-2-oleoylglycerol
210005
Cavia porcellus
CMP + diarachidonoylphosphatidylinositol
-
-
-
r
2.7.8.11
CDP-distearoylglycerol + myo-inositol
38% of the activity with CDP-1-stearoyl-2-oleoylglycerol
210005
Cavia porcellus
CMP + distearoylphosphatidylinositol
-
-
-
r
2.7.8.11
CDPdipalmitoyl-sn-glycerol + myo-inositol
70% of the activity with CDP-1-stearoyl-2-oleoylglycerol
210005
Cavia porcellus
CMP + dipalmitoylphosphatidylinositol
-
-
-
r
3.6.1.26
CDP-1-stearoyl-2-oleoylglycerol + H2O
-
210005
Cavia porcellus
CMP + 1-stearoyl-2-oleoyl-sn-glycerol-3-phosphate
-
210005
Cavia porcellus
?
3.6.1.26
CDP-1-stearoyl-2-stearoylglycerol + H2O
-
210005
Cavia porcellus
CMP + 1,2-distearoyl-sn-glycerol-3-phosphate
-
210005
Cavia porcellus
?
3.6.1.26
CDPdiacylglycerol + H2O
-
210005
Cavia porcellus
CMP + phosphatidate
-
210005
Cavia porcellus
?
3.6.1.26
CDPdipalmitoylglycerol + H2O
-
210005
Cavia porcellus
CMP + 1,2-dipalmitoyl-sn-glycerol-3-phosphate
-
210005
Cavia porcellus
?
3.6.1.26
CDPdistearoylglycerol + H2O
-
210005
Cavia porcellus
CMP + 1,2-distearoyl-sn-glycerol-3-phosphate
-
210005
Cavia porcellus
?
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.7.8.11
0.04
-
AMP
pH 8.3, 37°C
Cavia porcellus
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.6.1.26
Triton X-100
detergent required for activity, optimum concentration 0.3%
Cavia porcellus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.8.11
AMP
non-competitive inhibition
Cavia porcellus
3.6.1.26
AMP
none competitive, Ki: 0.04 mM
Cavia porcellus
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.7.8.11
0.04
-
AMP
pH 8.3, 37°C
Cavia porcellus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.7.8.11
0.03
-
CDP-1-stearoyl-2-oleoylglycerol
pH 8.3, 37°C
Cavia porcellus
2.7.8.11
0.045
-
1-stearoyl-2-arachidonoylglycerol
pH 8.3, 37°C
Cavia porcellus
2.7.8.11
0.05
-
dipalmitoyl-sn-glycerol
pH 8.3, 37°C
Cavia porcellus
2.7.8.11
0.16
-
CDP-distearoylglycerol
pH 8.3, 37°C
Cavia porcellus
3.6.1.26
0.04
-
CDP-1-stearoyl-2-oleoylglycerol
-
Cavia porcellus
3.6.1.26
0.047
-
CDP-1-stearoyl-2-stearoylglycerol
-
Cavia porcellus
3.6.1.26
0.063
-
CDPdipalmitoylglycerol
-
Cavia porcellus
3.6.1.26
0.14
-
CDPdistearoylglycerol
-
Cavia porcellus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.6.1.26
lysosome
-
Cavia porcellus
5764
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.8.11
CDP-diacylglycerol + myo-inositol
Cavia porcellus
-
CMP + phosphatidyl-1D-myo-inositol
-
Cavia porcellus
r
3.6.1.26
CDPdiacylglycerol + H2O
Cavia porcellus
-
CMP + phosphatidate
-
Cavia porcellus
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
3.6.1.26
-
Cavia porcellus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.8.11
brain
-
Cavia porcellus
-
3.6.1.26
brain
-
Cavia porcellus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.8.11
CDP-1-arachidonoyl-2-stearoylglycerol + myo-inositol
6% of the activity with CDP-1-stearoyl-2-oleoylglycerol
210005
Cavia porcellus
CMP + 1-arachidonoyl-2-stearoylphosphtidylinositol
-
-
-
r
2.7.8.11
CDP-1-stearoyl-2-arachidonoylglycerol + myo-inositol
4% of the activity with CDP-1-stearoyl-2-oleoylglycerol
210005
Cavia porcellus
CMP + 1-stearoyl-2-arachidonoylphosphatidylinositol
-
-
-
r
2.7.8.11
CDP-1-stearoyl-2-oleoylglycerol + myo-inositol
-
210005
Cavia porcellus
CMP + 1-stearoyl-2-oleoylphosphatidylinositol
-
-
-
r
2.7.8.11
CDP-diacylglycerol + myo-inositol
-
210005
Cavia porcellus
CMP + phosphatidyl-1D-myo-inositol
-
210005
Cavia porcellus
r
2.7.8.11
CDP-diarachidonoylglycerol + myo-inositol
9% of the activity with CDP-1-stearoyl-2-oleoylglycerol
210005
Cavia porcellus
CMP + diarachidonoylphosphatidylinositol
-
-
-
r
2.7.8.11
CDP-distearoylglycerol + myo-inositol
38% of the activity with CDP-1-stearoyl-2-oleoylglycerol
210005
Cavia porcellus
CMP + distearoylphosphatidylinositol
-
-
-
r
2.7.8.11
CDPdipalmitoyl-sn-glycerol + myo-inositol
70% of the activity with CDP-1-stearoyl-2-oleoylglycerol
210005
Cavia porcellus
CMP + dipalmitoylphosphatidylinositol
-
-
-
r
3.6.1.26
CDP-1-stearoyl-2-oleoylglycerol + H2O
-
210005
Cavia porcellus
CMP + 1-stearoyl-2-oleoyl-sn-glycerol-3-phosphate
-
210005
Cavia porcellus
?
3.6.1.26
CDP-1-stearoyl-2-stearoylglycerol + H2O
-
210005
Cavia porcellus
CMP + 1,2-distearoyl-sn-glycerol-3-phosphate
-
210005
Cavia porcellus
?
3.6.1.26
CDPdiacylglycerol + H2O
-
210005
Cavia porcellus
CMP + phosphatidate
-
210005
Cavia porcellus
?
3.6.1.26
CDPdipalmitoylglycerol + H2O
-
210005
Cavia porcellus
CMP + 1,2-dipalmitoyl-sn-glycerol-3-phosphate
-
210005
Cavia porcellus
?
3.6.1.26
CDPdistearoylglycerol + H2O
-
210005
Cavia porcellus
CMP + 1,2-distearoyl-sn-glycerol-3-phosphate
-
210005
Cavia porcellus
?