EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.6.1.23 | 5-Aminouracil | 5 mM, 50% loss of activity | Allium cepa | |
3.6.1.23 | 6-aminouracil | 5 mM, 60% loss of activity | Allium cepa | |
3.6.1.23 | EDTA | 1 mM, 65% loss of activity | Allium cepa | |
3.6.1.23 | KCl | 0.4 mM, 29% loss of activity | Allium cepa | |
3.6.1.23 | NEM | 12 mM, 14% loss of activity | Allium cepa | |
3.6.1.23 | Uracil | 5 mM, 30% loss of activity | Allium cepa |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.6.1.23 | 0.006 | - |
dUTP | - |
Allium cepa |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.6.1.23 | Mg2+ | Mg2+, Mn2+ or Zn2+ required for enzyme function | Allium cepa | |
3.6.1.23 | Mn2+ | Mg2+, Mn2+ or Zn2+ required for enzyme function | Allium cepa | |
3.6.1.23 | Zn2+ | Mg2+, Mn2+ or Zn2+ required for enzyme function | Allium cepa |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.6.1.23 | 36000 | - |
gel filtration | Allium cepa |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.6.1.23 | dUTP + H2O | Allium cepa | enzyme plays a key role in deoxyribonucleotide metabolism | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.6.1.23 | Allium cepa | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.6.1.23 | root | meristem cells, high levels of dUTPase in both resting and proliferating root meristem cells. Activity increase at the G1/S boundary, remains high throughout S phase, and shows almost undetectable levels during G1 and G2 | Allium cepa | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.6.1.23 | dCTP + H2O | no activity | Allium cepa | dCMP + diphosphate | - |
? | |
3.6.1.23 | dTTP + H2O | no activity | Allium cepa | dTMP + diphosphate | - |
? | |
3.6.1.23 | dUTP + H2O | - |
Allium cepa | dUMP + diphosphate | - |
? | |
3.6.1.23 | dUTP + H2O | enzyme plays a key role in deoxyribonucleotide metabolism | Allium cepa | ? | - |
? |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.6.1.23 | 37 | - |
5 min, stable | Allium cepa |
3.6.1.23 | 45 | - |
5 min, 28% loss of activity | Allium cepa |
3.6.1.23 | 55 | - |
5 min, complete inactivation | Allium cepa |