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Literature summary extracted from
- Human deoxyuridine triphosphate nucleotidohydrolase. Purification and characterization of the deoxyuridine triphosphate nucleotidohydrolase from acute lymphocytic leukemia (1979), J. Biol. Chem., 254, 2897-2901.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.6.1.23 | Cu2+ | 0.5 mM, 50% inhibition | Homo sapiens |  |
| 3.6.1.23 | EDTA | reversed by Mg2+ or Zn2+ | Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.6.1.23 | 0.001 | - |
dUTP | - |
Homo sapiens | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.6.1.23 | Mg2+ | maximal activity in presence of 0.04 mM Mg2+ | Homo sapiens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.6.1.23 | 43000 | - |
gel filtration | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.6.1.23 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.6.1.23 | partial | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.6.1.23 | blast cell | of patient with acute lymphocytic leukemia | Homo sapiens | - |
| 3.6.1.23 | HeLa cell | - |
Homo sapiens | - |
| 3.6.1.23 | HeLa-S3 cell | - |
Homo sapiens | - |
| 3.6.1.23 | KB cell | - |
Homo sapiens | - |
| 3.6.1.23 | RAJI cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.1.23 | dUTP + H2O | - |
Homo sapiens | dUMP + diphosphate | - |
? | |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.6.1.23 | additional information | - |
4 mM Mg2+ stabilizes at 37°C | Homo sapiens |
| 3.6.1.23 | 27 | 41 | 20 min, stable | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.6.1.23 | 7 | 8 | - |
Homo sapiens |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.6.1.23 | 6 | 9 | about 60% of maximal activity at pH 6.0 and at pH 9.0 | Homo sapiens |
| 3.6.1.23 | 7 | 8 | - |
Homo sapiens |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.6.1.23 | 0.5 | - |
Cu2+ | - |
Homo sapiens | |
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