EC Number | Cloned (Comment) | Organism |
---|---|---|
3.6.1.13 | expression as a thioredoxin fusion protein in Escherichia coli | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.6.1.13 | F- | IC50: 0.02 mM | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.6.1.13 | 0.06 | - |
ADP-ribose | pH 7.5, 37°C | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.6.1.13 | Mg2+ | optimal activity with 2.5-5 mM Mg2+ or 0.1-0.25 mM Mn2+ | Homo sapiens | |
3.6.1.13 | Mn2+ | optimal activity with 2.5-5 mM Mg2+ or 0.1-0.25 mM Mn2+ | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.6.1.13 | 24300 | - |
2 * 24300, native protein, mass spectrometry | Homo sapiens |
3.6.1.13 | 85000 | - |
dimeric thioredoxin fusion protein expressed in Escherichia coli, gel filtration | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.6.1.13 | ADP-ribose + H2O | Homo sapiens | the function of the enzyme might be to remove free ADP-ribose arising from NAD+ and protein-bound poly- and non-enzymic protein glycation | AMP + ribose 5-phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.6.1.13 | Homo sapiens | Q9UKK9 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.6.1.13 | - |
Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.6.1.13 | adrenal gland | - |
Homo sapiens | - |
3.6.1.13 | aorta | - |
Homo sapiens | - |
3.6.1.13 | bladder | - |
Homo sapiens | - |
3.6.1.13 | bone marrow | low activity | Homo sapiens | - |
3.6.1.13 | brain | - |
Homo sapiens | - |
3.6.1.13 | caudate nucleus | - |
Homo sapiens | - |
3.6.1.13 | caudate putamen | - |
Homo sapiens | - |
3.6.1.13 | cerebellum | - |
Homo sapiens | - |
3.6.1.13 | cerebral cortex | - |
Homo sapiens | - |
3.6.1.13 | colon | - |
Homo sapiens | - |
3.6.1.13 | frontal lobe | - |
Homo sapiens | - |
3.6.1.13 | heart | - |
Homo sapiens | - |
3.6.1.13 | hippocampus | - |
Homo sapiens | - |
3.6.1.13 | kidney | high activity | Homo sapiens | - |
3.6.1.13 | leukocyte | - |
Homo sapiens | - |
3.6.1.13 | liver | high activity | Homo sapiens | - |
3.6.1.13 | lung | - |
Homo sapiens | - |
3.6.1.13 | lymph node | low activity | Homo sapiens | - |
3.6.1.13 | mammary gland | - |
Homo sapiens | - |
3.6.1.13 | medulla oblongata | - |
Homo sapiens | - |
3.6.1.13 | nucleus accumbens | - |
Homo sapiens | - |
3.6.1.13 | occipital lobe | - |
Homo sapiens | - |
3.6.1.13 | ovary | - |
Homo sapiens | - |
3.6.1.13 | pancreas | - |
Homo sapiens | - |
3.6.1.13 | peripheral blood | - |
Homo sapiens | - |
3.6.1.13 | pituitary gland | high activity | Homo sapiens | - |
3.6.1.13 | placenta | high activity | Homo sapiens | - |
3.6.1.13 | prostate | - |
Homo sapiens | - |
3.6.1.13 | salivary gland | - |
Homo sapiens | - |
3.6.1.13 | skeletal muscle | - |
Homo sapiens | - |
3.6.1.13 | small intestine | - |
Homo sapiens | - |
3.6.1.13 | spinal cord | - |
Homo sapiens | - |
3.6.1.13 | spleen | - |
Homo sapiens | - |
3.6.1.13 | stomach | - |
Homo sapiens | - |
3.6.1.13 | substantia nigra | - |
Homo sapiens | - |
3.6.1.13 | temporal lobe | - |
Homo sapiens | - |
3.6.1.13 | testis | - |
Homo sapiens | - |
3.6.1.13 | thalamus | - |
Homo sapiens | - |
3.6.1.13 | thymus | high activity | Homo sapiens | - |
3.6.1.13 | thyroid gland | - |
Homo sapiens | - |
3.6.1.13 | trachea | - |
Homo sapiens | - |
3.6.1.13 | uterus | - |
Homo sapiens | - |
3.6.1.13 | vermiform appendix | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.6.1.13 | ADP-glucose + H2O | 56% of the activity with ADP-ribose | Homo sapiens | AMP + alpha-D-glucose 1-phosphate | - |
? | |
3.6.1.13 | ADP-mannose + H2O | 103% of the activity with ADP-ribose | Homo sapiens | AMP + D-mannose 1-phosphate | - |
? | |
3.6.1.13 | ADP-ribose + H2O | - |
Homo sapiens | AMP + ribose 5-phosphate | - |
? | |
3.6.1.13 | ADP-ribose + H2O | the function of the enzyme might be to remove free ADP-ribose arising from NAD+ and protein-bound poly- and non-enzymic protein glycation | Homo sapiens | AMP + ribose 5-phosphate | - |
? | |
3.6.1.13 | diadenosine 5',5''-diphosphate + H2O | 20% the activity with ADP-ribose | Homo sapiens | ? | - |
? | |
3.6.1.13 | GDP-glucose + H2O | 7% of the activity with ADP-ribose | Homo sapiens | GMP + glucose 5-phosphate | - |
? | |
3.6.1.13 | IDP-ribose + H2O | 9% of the activity with ADP-ribose | Homo sapiens | IMP + ribose 5-phosphate | - |
? | |
3.6.1.13 | NAD+ + H2O | 7% of the activity with ADP-ribose | Homo sapiens | AMP + NMN | - |
? | |
3.6.1.13 | NADH + H2O | 7% of the activity with ADP-ribose | Homo sapiens | AMP + NMNH | - |
? | |
3.6.1.13 | NADPH + H2O | 12% of the activity with ADP-ribose | Homo sapiens | AMP + ? | - |
? | |
3.6.1.13 | UDP-galactose + H2O | 7% of the activity with ADP-ribose | Homo sapiens | UDP + galactose | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.6.1.13 | dimer | 2 * 24300, native protein, mass spectrometry | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.6.1.13 | adenosine 5'-diphosphosugar pyrophosphatase | - |
Homo sapiens |
3.6.1.13 | YSA1H | - |
Homo sapiens |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.6.1.13 | 5.5 | - |
ADP-ribose | pH 7.5, 37°C | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.6.1.13 | 7.4 | 9 | with 2.5-5 mM Mg2+ or 0.1-0.25 mM Mn2+ | Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.6.1.13 | 0.02 | - |
IC50: 0.02 mM | Homo sapiens | F- |