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Literature summary extracted from

  • Providenzia, R.; Bass, S.T.; Hansen, R.G.
    A pyrophosphatase from mammalian tissues specific for derivatives of ADP (1968), Biochim. Biophys. Acta, 167, 199-201.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.21 ADP Ki: 0.075 mM Bos taurus
3.6.1.21 ADP Ki: 0.075 mM Oryctolagus cuniculus
3.6.1.21 ADP Ki: 0.075 mM Rattus norvegicus
3.6.1.21 ATP Ki: 0.165 mM Bos taurus
3.6.1.21 ATP Ki: 0.165 mM Oryctolagus cuniculus
3.6.1.21 ATP Ki: 0.165 mM Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.1.21 0.29
-
 ADP-Glc
-
 Rattus norvegicus
3.6.1.21 0.29
-
 ADP-Glc
-
 Bos taurus
3.6.1.21 0.29
-
 ADP-Glc
-
 Oryctolagus cuniculus
3.6.1.21 1.3
-
 ADP-Rib
-
 Rattus norvegicus
3.6.1.21 1.3
-
 ADP-Rib
-
 Bos taurus
3.6.1.21 1.3
-
 ADP-Rib
-
 Oryctolagus cuniculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.21 Mg2+ divalent cation required for full activity, Mg2+ at concentration of 0.4 mM most effective Rattus norvegicus
3.6.1.21 Mg2+ divalent cation required for full activity, Mg2+ at concentration of 0.4 mM most effective Bos taurus
3.6.1.21 Mg2+ divalent cation required for full activity, Mg2+ at concentration of 0.4 mM most effective Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.21 ADP-sugar + H2O Rattus norvegicus
-
 AMP + sugar phosphate
-
 ?
3.6.1.21 ADP-sugar + H2O Bos taurus
-
 AMP + sugar phosphate
-
 ?
3.6.1.21 ADP-sugar + H2O Oryctolagus cuniculus
-
 AMP + sugar phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.21 Bos taurus
-
-
-
3.6.1.21 Oryctolagus cuniculus
-
-
-
3.6.1.21 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.1.21 partial Rattus norvegicus
3.6.1.21 partial Bos taurus
3.6.1.21 partial Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.21 brain
-
 Rattus norvegicus
-
3.6.1.21 brain
-
 Oryctolagus cuniculus
-
3.6.1.21 kidney
-
 Rattus norvegicus
-
3.6.1.21 kidney
-
 Oryctolagus cuniculus
-
3.6.1.21 liver
-
 Bos taurus
-
3.6.1.21 liver
-
 Oryctolagus cuniculus
-
3.6.1.21 mammary gland
-
 Rattus norvegicus
-
3.6.1.21 mammary gland
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.21 ADP-Glc + H2O
-
 Rattus norvegicus AMP + Glc-1-phosphate
-
 ?
3.6.1.21 ADP-Glc + H2O
-
 Bos taurus AMP + Glc-1-phosphate
-
 ?
3.6.1.21 ADP-Glc + H2O
-
 Oryctolagus cuniculus AMP + Glc-1-phosphate
-
 ?
3.6.1.21 ADP-Man + H2O
-
 Rattus norvegicus AMP + Man-1-phosphate
-
 ?
3.6.1.21 ADP-Man + H2O
-
 Bos taurus AMP + Man-1-phosphate
-
 ?
3.6.1.21 ADP-Man + H2O
-
 Oryctolagus cuniculus AMP + Man-1-phosphate
-
 ?
3.6.1.21 ADP-Rib + H2O
-
 Rattus norvegicus AMP + Rib-5-phosphate
-
 ?
3.6.1.21 ADP-Rib + H2O
-
 Bos taurus AMP + Rib-5-phosphate
-
 ?
3.6.1.21 ADP-Rib + H2O
-
 Oryctolagus cuniculus AMP + Rib-5-phosphate
-
 ?
3.6.1.21 ADP-sugar + H2O
-
 Rattus norvegicus AMP + sugar phosphate
-
 ?
3.6.1.21 ADP-sugar + H2O
-
 Bos taurus AMP + sugar phosphate
-
 ?
3.6.1.21 ADP-sugar + H2O
-
 Oryctolagus cuniculus AMP + sugar phosphate
-
 ?
3.6.1.21 FAD + H2O very poor substrate Rattus norvegicus AMP + FMN
-
 ?
3.6.1.21 FAD + H2O very poor substrate Bos taurus AMP + FMN
-
 ?
3.6.1.21 FAD + H2O very poor substrate Oryctolagus cuniculus AMP + FMN
-
 ?
3.6.1.21 NAD+ + H2O very poor substrate Rattus norvegicus AMP + NMN
-
 ?
3.6.1.21 NAD+ + H2O very poor substrate Bos taurus AMP + NMN
-
 ?
3.6.1.21 NAD+ + H2O very poor substrate Oryctolagus cuniculus AMP + NMN
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.6.1.21 7.8 8.4 with ADP-Glc as substrate Rattus norvegicus
3.6.1.21 7.8 8.4 with ADP-Glc as substrate Bos taurus
3.6.1.21 7.8 8.4 with ADP-Glc as substrate Oryctolagus cuniculus