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Literature summary extracted from
- Fluoride is a strong specific inhibitor of (asymmetrical) Ap4A hydrolases (1990), FEBS Lett., 262, 205-208.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.6.1.17 | fluoride | non-competitive, strong inhibition, reversible | Bos taurus |  |
| 3.6.1.17 | fluoride | non-competitive, strong inhibition, reversible | Cucurbita pepo | |
| 3.6.1.17 | fluoride | non-competitive, strong inhibition, reversible | Helianthus sp. | |
| 3.6.1.17 | fluoride | non-competitive, strong inhibition, reversible | Lupinus sp. | |
| 3.6.1.17 | fluoride | non-competitive, strong inhibition, reversible | Saccharomyces cerevisiae | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.1.17 | P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | Lupinus sp. | - |
ATP + AMP | - |
? | |
| 3.6.1.17 | P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | Saccharomyces cerevisiae | - |
ATP + AMP | - |
? | |
| 3.6.1.17 | P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | Bos taurus | - |
ATP + AMP | - |
? | |
| 3.6.1.17 | P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | Cucurbita pepo | - |
ATP + AMP | - |
? | |
| 3.6.1.17 | P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | Helianthus sp. | - |
ATP + AMP | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.6.1.17 | Bos taurus | - |
- |
- |
| 3.6.1.17 | Cucurbita pepo | - |
marrow | - |
| 3.6.1.17 | Helianthus sp. | - |
sunflower | - |
| 3.6.1.17 | Lupinus sp. | - |
yellow lupin | - |
| 3.6.1.17 | Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.6.1.17 | - |
Lupinus sp. |
| 3.6.1.17 | - |
Saccharomyces cerevisiae |
| 3.6.1.17 | - |
Bos taurus |
| 3.6.1.17 | - |
Cucurbita pepo |
| 3.6.1.17 | - |
Helianthus sp. |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.6.1.17 | liver | - |
Bos taurus | - |
| 3.6.1.17 | seed | - |
Lupinus sp. | - |
| 3.6.1.17 | seed | - |
Cucurbita pepo | - |
| 3.6.1.17 | seed | - |
Helianthus sp. | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.1.17 | P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | - |
Lupinus sp. | ATP + AMP | - |
? | |
| 3.6.1.17 | P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | - |
Saccharomyces cerevisiae | ATP + AMP | - |
? | |
| 3.6.1.17 | P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | - |
Bos taurus | ATP + AMP | - |
? | |
| 3.6.1.17 | P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | - |
Cucurbita pepo | ATP + AMP | - |
? | |
| 3.6.1.17 | P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | - |
Helianthus sp. | ATP + AMP | - |
? | |
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