BRENDA - Enzyme Database

Fluoride is a strong specific inhibitor of (asymmetrical) Ap4A hydrolases

Guranowski, A.; FEBS Lett. 262, 205-208 (1990)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.6.1.17
fluoride
non-competitive, strong inhibition, reversible
Bos taurus
3.6.1.17
fluoride
non-competitive, strong inhibition, reversible
Cucurbita pepo
3.6.1.17
fluoride
non-competitive, strong inhibition, reversible
Helianthus sp.
3.6.1.17
fluoride
non-competitive, strong inhibition, reversible
Lupinus sp.
3.6.1.17
fluoride
non-competitive, strong inhibition, reversible
Saccharomyces cerevisiae
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
Lupinus sp.
-
ATP + AMP
-
Lupinus sp.
?
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
Saccharomyces cerevisiae
-
ATP + AMP
-
Saccharomyces cerevisiae
?
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
Bos taurus
-
ATP + AMP
-
Bos taurus
?
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
Cucurbita pepo
-
ATP + AMP
-
Cucurbita pepo
?
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
Helianthus sp.
-
ATP + AMP
-
Helianthus sp.
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.6.1.17
Bos taurus
-
-
-
3.6.1.17
Cucurbita pepo
-
marrow
-
3.6.1.17
Helianthus sp.
-
sunflower
-
3.6.1.17
Lupinus sp.
-
yellow lupin
-
3.6.1.17
Saccharomyces cerevisiae
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
3.6.1.17
-
Bos taurus
3.6.1.17
-
Cucurbita pepo
3.6.1.17
-
Helianthus sp.
3.6.1.17
-
Saccharomyces cerevisiae
3.6.1.17
-
Lupinus sp.
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.6.1.17
liver
-
Bos taurus
-
3.6.1.17
seed
-
Cucurbita pepo
-
3.6.1.17
seed
-
Helianthus sp.
-
3.6.1.17
seed
-
Lupinus sp.
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
209907
Lupinus sp.
ATP + AMP
-
209907
Lupinus sp.
?
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
209907
Saccharomyces cerevisiae
ATP + AMP
-
209907
Saccharomyces cerevisiae
?
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
209907
Bos taurus
ATP + AMP
-
209907
Bos taurus
?
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
209907
Cucurbita pepo
ATP + AMP
-
209907
Cucurbita pepo
?
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
209907
Helianthus sp.
ATP + AMP
-
209907
Helianthus sp.
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.6.1.17
fluoride
non-competitive, strong inhibition, reversible
Bos taurus
3.6.1.17
fluoride
non-competitive, strong inhibition, reversible
Cucurbita pepo
3.6.1.17
fluoride
non-competitive, strong inhibition, reversible
Helianthus sp.
3.6.1.17
fluoride
non-competitive, strong inhibition, reversible
Lupinus sp.
3.6.1.17
fluoride
non-competitive, strong inhibition, reversible
Saccharomyces cerevisiae
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
Lupinus sp.
-
ATP + AMP
-
Lupinus sp.
?
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
Saccharomyces cerevisiae
-
ATP + AMP
-
Saccharomyces cerevisiae
?
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
Bos taurus
-
ATP + AMP
-
Bos taurus
?
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
Cucurbita pepo
-
ATP + AMP
-
Cucurbita pepo
?
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
Helianthus sp.
-
ATP + AMP
-
Helianthus sp.
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
3.6.1.17
-
Bos taurus
3.6.1.17
-
Cucurbita pepo
3.6.1.17
-
Helianthus sp.
3.6.1.17
-
Saccharomyces cerevisiae
3.6.1.17
-
Lupinus sp.
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.6.1.17
liver
-
Bos taurus
-
3.6.1.17
seed
-
Cucurbita pepo
-
3.6.1.17
seed
-
Helianthus sp.
-
3.6.1.17
seed
-
Lupinus sp.
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
209907
Lupinus sp.
ATP + AMP
-
209907
Lupinus sp.
?
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
209907
Saccharomyces cerevisiae
ATP + AMP
-
209907
Saccharomyces cerevisiae
?
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
209907
Bos taurus
ATP + AMP
-
209907
Bos taurus
?
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
209907
Cucurbita pepo
ATP + AMP
-
209907
Cucurbita pepo
?
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
209907
Helianthus sp.
ATP + AMP
-
209907
Helianthus sp.
?