BRENDA - Enzyme Database

Bis-(5-guanosyl) tetraphosphatase in rat tissues

Cameselle, J.C.; Costas, M.J.; Sillero, M.A.G.; Sillero, A.; Biochem. J. 201, 405-410 (1982)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.6.1.17
Ca2+
50% inhibition at 0.025 mM
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.6.1.17
cytosol
-
Rattus norvegicus
5829
-
3.6.1.17
nucleus
activity found in cytosol and nucleus, changing separation depending on tissue
Rattus norvegicus
5634
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
3.6.1.17
Mg2+
required
Rattus norvegicus
3.6.1.17
Mn2+
required, more effective than Mg2+
Rattus norvegicus
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
3.6.1.17
19900
22000
gel filtration, exact MW depending on tissue
Rattus norvegicus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
Rattus norvegicus
-
ATP + AMP
-
Rattus norvegicus
?
3.6.1.17
P1,P4-bis(5'-guanosyl)tetraphosphate + H2O
Rattus norvegicus
-
GTP + GMP
-
Rattus norvegicus
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.6.1.17
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.6.1.17
brain
-
Rattus norvegicus
-
3.6.1.17
intestinal mucosa
-
Rattus norvegicus
-
3.6.1.17
kidney
-
Rattus norvegicus
-
3.6.1.17
liver
-
Rattus norvegicus
-
3.6.1.17
muscle
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
209898
Rattus norvegicus
ATP + AMP
-
209898
Rattus norvegicus
?
3.6.1.17
P1,P4-bis(5'-guanosyl)tetraphosphate + H2O
-
209898
Rattus norvegicus
GTP + GMP
-
209898
Rattus norvegicus
?
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
3.6.1.17
7
8.5
depending on tissue
Rattus norvegicus
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
3.6.1.17
0.025
-
Ca2+
-
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.6.1.17
Ca2+
50% inhibition at 0.025 mM
Rattus norvegicus
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
3.6.1.17
0.025
-
Ca2+
-
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.6.1.17
cytosol
-
Rattus norvegicus
5829
-
3.6.1.17
nucleus
activity found in cytosol and nucleus, changing separation depending on tissue
Rattus norvegicus
5634
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
3.6.1.17
Mg2+
required
Rattus norvegicus
3.6.1.17
Mn2+
required, more effective than Mg2+
Rattus norvegicus
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
3.6.1.17
19900
22000
gel filtration, exact MW depending on tissue
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
Rattus norvegicus
-
ATP + AMP
-
Rattus norvegicus
?
3.6.1.17
P1,P4-bis(5'-guanosyl)tetraphosphate + H2O
Rattus norvegicus
-
GTP + GMP
-
Rattus norvegicus
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.6.1.17
brain
-
Rattus norvegicus
-
3.6.1.17
intestinal mucosa
-
Rattus norvegicus
-
3.6.1.17
kidney
-
Rattus norvegicus
-
3.6.1.17
liver
-
Rattus norvegicus
-
3.6.1.17
muscle
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
209898
Rattus norvegicus
ATP + AMP
-
209898
Rattus norvegicus
?
3.6.1.17
P1,P4-bis(5'-guanosyl)tetraphosphate + H2O
-
209898
Rattus norvegicus
GTP + GMP
-
209898
Rattus norvegicus
?
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
3.6.1.17
7
8.5
depending on tissue
Rattus norvegicus