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Literature summary extracted from

  • Cameselle, J.C.; Costas, M.J.; Sillero, M.A.G.; Sillero, A.
    Bis-(5-guanosyl) tetraphosphatase in rat tissues (1982), Biochem. J., 201, 405-410.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.17 Ca2+ 50% inhibition at 0.025 mM Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.1.17 cytosol
-
 Rattus norvegicus 5829
-
3.6.1.17 nucleus activity found in cytosol and nucleus, changing separation depending on tissue Rattus norvegicus 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.17 Mg2+ required Rattus norvegicus
3.6.1.17 Mn2+ required, more effective than Mg2+ Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.6.1.17 19900 22000 gel filtration, exact MW depending on tissue Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.17 P1,P4-bis(5'-adenosyl) tetraphosphate + H2O Rattus norvegicus
-
 ATP + AMP
-
 ?
3.6.1.17 P1,P4-bis(5'-guanosyl)tetraphosphate + H2O Rattus norvegicus
-
 GTP + GMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.17 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.17 brain
-
 Rattus norvegicus
-
3.6.1.17 intestinal mucosa
-
 Rattus norvegicus
-
3.6.1.17 kidney
-
 Rattus norvegicus
-
3.6.1.17 liver
-
 Rattus norvegicus
-
3.6.1.17 muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.17 P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
 Rattus norvegicus ATP + AMP
-
 ?
3.6.1.17 P1,P4-bis(5'-guanosyl)tetraphosphate + H2O
-
 Rattus norvegicus GTP + GMP
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.6.1.17 7 8.5 depending on tissue Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.6.1.17 0.025
-
 Ca2+
-
 Rattus norvegicus