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Literature summary extracted from

  • Cohen, L.; MacKenzie, R.E.
    Methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase from porcine liver. Interaction between the dehydrogenase and cyclohydrolase activities of the multifunctional enzyme (1978), Biochim. Biophys. Acta, 522, 311-317.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.5 folic acid
-
Sus scrofa
1.5.1.5 NADPH against NADP+ and methylentetrahydrofolate Sus scrofa
3.5.4.9 folate competitive inhibition Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.9 10-formyltetrahydrofolate Sus scrofa
-
5,10-methenyltetrahydrofolate + H2O
-
r
3.5.4.9 5,10-methenyltetrahydrofolate + H2O Sus scrofa
-
10-formyltetrahydrofolate
-
r
3.5.4.9 5,10-methenyltetrahydrofolate + H2O Saccharomyces cerevisiae
-
10-formyltetrahydrofolate
-
?
3.5.4.9 5,10-methenyltetrahydrofolate + H2O Ovis aries
-
10-formyltetrahydrofolate
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.5 Sus scrofa
-
-
-
3.5.4.9 Ovis aries
-
sheep, trifunctional enzyme
-
3.5.4.9 Saccharomyces cerevisiae
-
yeast, trifunctional enzyme
-
3.5.4.9 Sus scrofa
-
pig, trifunctional enzyme
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.1.5 trifunctional enzyme: methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrase, formyltetrahydrofolate synthetase Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.5 liver
-
Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.9 10-formyltetrahydrofolate
-
Sus scrofa 5,10-methenyltetrahydrofolate + H2O
-
r
3.5.4.9 5,10-methenyltetrahydrofolate + H2O
-
Sus scrofa 10-formyltetrahydrofolate
-
r
3.5.4.9 5,10-methenyltetrahydrofolate + H2O
-
Saccharomyces cerevisiae 10-formyltetrahydrofolate
-
?
3.5.4.9 5,10-methenyltetrahydrofolate + H2O
-
Ovis aries 10-formyltetrahydrofolate
-
?