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Literature summary extracted from

  • Carlow, D.C.; Carter, C.W.; Mejlhede, N.; Neuhard, J.; Wolfenden, R.
    Cytidine deaminases from B. subtilis and E. coli: Compensating effects of changing zinc coordination and quaternary structure (1999), Biochemistry, 38, 12258-12265.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.4.5 SO268 harboring plasmid pSO143 containing the B. subtilis cytidine deaminase gene Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.5 1-(beta-D-ribofuranosyl)-dihydropyrimidine-2-one
-
 Bacillus subtilis
3.5.4.5 1-(beta-D-ribofuranosyl)-dihydropyrimidine-2-one
-
 Escherichia coli
3.5.4.5 1-(beta-D-ribofuranosyl)-dihydropyrimidine-2-one
-
 Homo sapiens
3.5.4.5 3,4,5,6,tetrahydrozebularine
-
 Bacillus subtilis
3.5.4.5 3,4,5,6,tetrahydrozebularine
-
 Escherichia coli
3.5.4.5 3,4-dihydrouridine
-
 Bacillus subtilis
3.5.4.5 3,4-dihydrouridine
-
 Escherichia coli
3.5.4.5 3,4-dihydrozebularine
-
 Bacillus subtilis
3.5.4.5 3,4-dihydrozebularine
-
 Escherichia coli
3.5.4.5 5-fluorozebularine
-
 Bacillus subtilis
3.5.4.5 5-fluorozebularine
-
 Escherichia coli

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.4.5 14800
-
 4 * 14800 Bacillus subtilis
3.5.4.5 31540
-
 2 * 31540 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.5 cytidine + H2O Bacillus subtilis
-
 uridine + NH3
-
 ?
3.5.4.5 cytidine + H2O Escherichia coli
-
 uridine + NH3
-
 ?
3.5.4.5 cytidine + H2O Homo sapiens
-
 uridine + NH3
-
 ?
3.5.4.5 cytidine + H2O Escherichia coli SO268
-
 uridine + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.5 Bacillus subtilis
-
-
-
3.5.4.5 Escherichia coli
-
-
-
3.5.4.5 Escherichia coli SO268
-
-
-
3.5.4.5 Homo sapiens
-
 human
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.4.5 238
-
-
 Bacillus subtilis
3.5.4.5 570
-
-
 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.5 cytidine + H2O
-
 Bacillus subtilis uridine + NH3
-
 ?
3.5.4.5 cytidine + H2O
-
 Escherichia coli uridine + NH3
-
 ?
3.5.4.5 cytidine + H2O
-
 Homo sapiens uridine + NH3
-
 ?
3.5.4.5 cytidine + H2O
-
 Escherichia coli SO268 uridine + NH3
-
 ?

Subunits

EC Number Subunits Comment Organism
3.5.4.5 dimer 2 * 31540 Escherichia coli
3.5.4.5 tetramer 4 * 14800 Bacillus subtilis

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.5.4.5 3.8 7.5
-
 Bacillus subtilis
3.5.4.5 3.8 7.5
-
 Escherichia coli