BRENDA - Enzyme Database show

Purification of human cytidine deaminase: Molecular and enzymatic characterization and inhibition by synthetic pyrimidine analogs

Cacciamani, T.; Vita, A.; Cristalli, G.; Vincenzetti, S.; Natalini, P.; Ruggieri, S.; Amici, A.; Magni, G.; Arch. Biochem. Biophys. 290, 285-292 (1991)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
3.5.4.5
medicine
enzyme limits the effectiveness of the antineoplastic agent cytosine arabinoside or aracytidine in the treatment of acute myeloblastic leukemias, chemotherapeutic use of the inhibitor THU to protect antileukemic agents from deaminase attack, inhibitors of cytidine deaminase prolongs the plasma halflife of antitumor or antiviral drugs
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.5.4.5
2'-deoxyuridine
-
Homo sapiens
3.5.4.5
2-thio-6-azarudine
-
Homo sapiens
3.5.4.5
3'-azido-3'-deoxythymidine
-
Homo sapiens
3.5.4.5
3-deazauridine
-
Homo sapiens
3.5.4.5
4-amino-1-(5-hydroxypentyl)pyrimidin-2(1H)-one
-
Homo sapiens
3.5.4.5
4-amino-1-hexyl-5,6-dihydropyrimidin-2(1H)-one
-
Homo sapiens
3.5.4.5
4-hydroxy-1-(beta-D-ribofuranosyl)piperidin-2-one
-
Homo sapiens
3.5.4.5
5,6-Dihydrouridine
-
Escherichia coli
3.5.4.5
5,6-Dihydrouridine
-
Homo sapiens
3.5.4.5
5-(Chloromercuri)cytidine
-
Escherichia coli
3.5.4.5
5-(Chloromercuri)cytidine
-
Homo sapiens
3.5.4.5
5-Bromouridine
-
Homo sapiens
3.5.4.5
5-fluoro-2'-deoxyuridine
-
Homo sapiens
3.5.4.5
5-fluorouridine
-
Homo sapiens
3.5.4.5
5-iodo-2'-deoxyuridine
-
Homo sapiens
3.5.4.5
5-methyluridine
-
Homo sapiens
3.5.4.5
5-{(1E)-3-[(5-carboxypentyl)amino]-3-oxoprop-1-en-1-yl}-5,6-dihydrocytidine
-
Homo sapiens
3.5.4.5
6-azauridine
-
Homo sapiens
3.5.4.5
Ag+
-
Homo sapiens
3.5.4.5
ara-U
-
Homo sapiens
3.5.4.5
CMP
-
Homo sapiens
3.5.4.5
Cu2+
-
Escherichia coli
3.5.4.5
Cu2+
-
Homo sapiens
3.5.4.5
Cu2+
-
Mus musculus
3.5.4.5
dCMP
-
Homo sapiens
3.5.4.5
deoxyadenosine
-
Escherichia coli
3.5.4.5
deoxyadenosine
-
Homo sapiens
3.5.4.5
DTNB
-
Homo sapiens
3.5.4.5
DTNB
-
Mus musculus
3.5.4.5
dTTP
-
Homo sapiens
3.5.4.5
dTTP
-
Mus musculus
3.5.4.5
Hg+
-
Escherichia coli
3.5.4.5
Hg+
-
Homo sapiens
3.5.4.5
Hg+
-
Mus musculus
3.5.4.5
N-ethylmaleimide
weak inhibition
Homo sapiens
3.5.4.5
N-ethylmaleimide
-
Mus musculus
3.5.4.5
p-chloromercuribenzoate
-
Homo sapiens
3.5.4.5
pseudouridine
-
Homo sapiens
3.5.4.5
thymidine
-
Escherichia coli
3.5.4.5
thymidine
-
Homo sapiens
3.5.4.5
thymine riboside
-
Homo sapiens
3.5.4.5
thymine riboside
-
Escherichia coli
3.5.4.5
uridine
-
Escherichia coli
3.5.4.5
uridine
-
Homo sapiens
3.5.4.5
UTP
-
Homo sapiens
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
3.5.4.5
13500
-
4 * 13500, SDS-PAGE
Homo sapiens
3.5.4.5
52000
-
gel filtration
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.5.4.5
cytidine + H2O
Gallus gallus
-
uridine + NH3
-
-
?
3.5.4.5
cytidine + H2O
Mus musculus
-
uridine + NH3
-
-
?
3.5.4.5
cytidine + H2O
Escherichia coli
-
uridine + NH3
-
-
?
3.5.4.5
cytidine + H2O
Homo sapiens
-
uridine + NH3
-
-
?
3.5.4.5
cytidine + H2O
Canis lupus familiaris
-
uridine + NH3
-
-
?
3.5.4.5
cytidine + H2O
Mus musculus BALB/c
-
uridine + NH3
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.5.4.5
Canis lupus familiaris
-
-
-
3.5.4.5
Escherichia coli
-
-
-
3.5.4.5
Gallus gallus
-
chicken
-
3.5.4.5
Homo sapiens
-
human
-
3.5.4.5
Mus musculus
-
BALB/c; mouse
-
3.5.4.5
Mus musculus BALB/c
-
BALB/c
-
3.5.4.5
no activity in Lactobacillus sp.
-
-
-
3.5.4.5
no activity in Moraxella sp.
-
Neisseria meningitidis
-
3.5.4.5
no activity in Pseudomonas sp.
-
P. acidovorans
-
Purification (Commentary)
EC Number
Commentary
Organism
3.5.4.5
-
Gallus gallus
3.5.4.5
-
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.5.4.5
granulocyte
normal and leukemic
Homo sapiens
-
3.5.4.5
liver
-
Canis lupus familiaris
-
3.5.4.5
liver
-
Gallus gallus
-
3.5.4.5
liver
-
Mus musculus
-
3.5.4.5
liver
-
Homo sapiens
-
3.5.4.5
lymphocyte
-
Homo sapiens
-
3.5.4.5
placenta
-
Homo sapiens
-
3.5.4.5
reticulocyte
-
Homo sapiens
-
3.5.4.5
spleen
-
Mus musculus
-
3.5.4.5
spleen
-
Homo sapiens
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
3.5.4.5
64.1
-
-
Homo sapiens
Storage Stability
EC Number
Storage Stability
Organism
3.5.4.5
-20°C, 20% glycerol appears to be necessary to prevent inactivation from occuring after freezing and thawing
Homo sapiens
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.4.5
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine + H2O
-
209661
Homo sapiens
?
-
-
-
?
3.5.4.5
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine + H2O
-
209661
Canis lupus familiaris
?
-
-
-
?
3.5.4.5
1-beta-D-arabinofuranosylcytosine + H2O
-
209661
Mus musculus
?
-
-
-
?
3.5.4.5
1-beta-D-arabinofuranosylcytosine + H2O
-
209661
Escherichia coli
?
-
-
-
?
3.5.4.5
1-beta-D-arabinofuranosylcytosine + H2O
-
209661
Homo sapiens
?
-
-
-
?
3.5.4.5
1-beta-D-arabinofuranosylcytosine + H2O
-
209661
Canis lupus familiaris
?
-
-
-
?
3.5.4.5
2'-deoxycytidine + H2O
-
209661
Mus musculus
2'-deoxyuridine + NH3
-
-
-
?
3.5.4.5
2'-deoxycytidine + H2O
-
209661
Escherichia coli
2'-deoxyuridine + NH3
-
-
-
?
3.5.4.5
2'-deoxycytidine + H2O
-
209661
Homo sapiens
2'-deoxyuridine + NH3
-
-
-
?
3.5.4.5
2'-deoxycytidine + H2O
-
209661
Mus musculus BALB/c
2'-deoxyuridine + NH3
-
-
-
?
3.5.4.5
2'-fluoro-2'-deoxycytidine + H2O
-
209661
Escherichia coli
2'-fluoro-2'-deoxyuridine + NH3
-
-
-
?
3.5.4.5
2'-fluoro-2'-deoxycytidine + H2O
-
209661
Homo sapiens
2'-fluoro-2'-deoxyuridine + NH3
-
-
-
?
3.5.4.5
5'-methyl-2'-deoxycytidine + H2O
-
209661
Mus musculus
5'-methyl-2-deoxyuridine + NH3
-
-
-
?
3.5.4.5
5'-methyl-2'-deoxycytidine + H2O
-
209661
Escherichia coli
5'-methyl-2-deoxyuridine + NH3
-
-
-
?
3.5.4.5
5'-methyl-2'-deoxycytidine + H2O
-
209661
Homo sapiens
5'-methyl-2-deoxyuridine + NH3
-
-
-
?
3.5.4.5
5'-methyl-2'-deoxycytidine + H2O
-
209661
Mus musculus BALB/c
5'-methyl-2-deoxyuridine + NH3
-
-
-
?
3.5.4.5
5-azacytidine + H2O
-
209661
Escherichia coli
5-azauridine + NH3
-
-
-
?
3.5.4.5
5-azacytidine + H2O
-
209661
Homo sapiens
5-azauridine + NH3
-
-
-
?
3.5.4.5
5-azadeoxycytidine + H2O
-
209661
Homo sapiens
5-azadeoxyuridine + NH3
-
-
-
?
3.5.4.5
5-iodo-2'-deoxycytidine
-
209661
Homo sapiens
5-iodo-2'-deoxyuridine + NH3
-
-
-
?
3.5.4.5
5-iododeoxycytidine + H2O
-
209661
Mus musculus
5-iododeoxyuridine + NH3
-
-
-
?
3.5.4.5
5-iododeoxycytidine + H2O
-
209661
Homo sapiens
5-iododeoxyuridine + NH3
-
-
-
?
3.5.4.5
5-methylcytidine + H2O
-
209661
Escherichia coli
5-methyluridine + NH3
-
-
-
?
3.5.4.5
5-methylcytidine + H2O
-
209661
Homo sapiens
5-methyluridine + NH3
-
-
-
?
3.5.4.5
cytidine + H2O
-
209661
Gallus gallus
uridine + NH3
-
-
-
?
3.5.4.5
cytidine + H2O
-
209661
Mus musculus
uridine + NH3
-
-
-
?
3.5.4.5
cytidine + H2O
-
209661
Escherichia coli
uridine + NH3
-
-
-
?
3.5.4.5
cytidine + H2O
-
209661
Homo sapiens
uridine + NH3
-
-
-
?
3.5.4.5
cytidine + H2O
-
209661
Canis lupus familiaris
uridine + NH3
-
-
-
?
3.5.4.5
cytidine + H2O
-
209661
Mus musculus BALB/c
uridine + NH3
-
-
-
?
3.5.4.5
cytosine arabinoside + H2O
-
209661
Mus musculus
uridine arabinoside + NH3
-
-
-
?
3.5.4.5
cytosine arabinoside + H2O
-
209661
Escherichia coli
uridine arabinoside + NH3
-
-
-
?
3.5.4.5
cytosine arabinoside + H2O
-
209661
Homo sapiens
uridine arabinoside + NH3
-
-
-
?
3.5.4.5
cytosine arabinoside + H2O
-
209661
Mus musculus BALB/c
uridine arabinoside + NH3
-
-
-
?
3.5.4.5
deoxycytidine + H2O
-
209661
Mus musculus
deoxyuridine + NH3
-
-
-
?
3.5.4.5
deoxycytidine + H2O
-
209661
Escherichia coli
deoxyuridine + NH3
-
-
-
?
3.5.4.5
deoxycytidine + H2O
-
209661
Homo sapiens
deoxyuridine + NH3
-
-
-
?
3.5.4.5
deoxycytidine + H2O
-
209661
Canis lupus familiaris
deoxyuridine + NH3
-
-
-
?
3.5.4.5
deoxycytidine + H2O
-
209661
Mus musculus BALB/c
deoxyuridine + NH3
-
-
-
?
3.5.4.5
additional information
-
209661
Escherichia coli
?
-
-
-
-
3.5.4.5
additional information
3-methylcytidine, cytosine and cyclocytidine are no substrates
209661
Homo sapiens
?
-
-
-
-
Subunits
EC Number
Subunits
Commentary
Organism
3.5.4.5
tetramer
-
Gallus gallus
3.5.4.5
tetramer
4 * 13500, SDS-PAGE
Homo sapiens
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
3.5.4.5
7.5
-
-
Homo sapiens
pH Range
EC Number
pH Minimum
pH Maximum
Commentary
Organism
3.5.4.5
3.5
10.5
deoxycytidine as substrate, beyond these values irreversible inactivation occurs
Homo sapiens
pH Stability
EC Number
pH Stability
pH Stability Maximum
Commentary
Organism
3.5.4.5
3.5
10.5
deoxycytidine as substrate, beyond these extremes rapid inactivation
Homo sapiens
Application (protein specific)
EC Number
Application
Commentary
Organism
3.5.4.5
medicine
enzyme limits the effectiveness of the antineoplastic agent cytosine arabinoside or aracytidine in the treatment of acute myeloblastic leukemias, chemotherapeutic use of the inhibitor THU to protect antileukemic agents from deaminase attack, inhibitors of cytidine deaminase prolongs the plasma halflife of antitumor or antiviral drugs
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.5.4.5
2'-deoxyuridine
-
Homo sapiens
3.5.4.5
2-thio-6-azarudine
-
Homo sapiens
3.5.4.5
3'-azido-3'-deoxythymidine
-
Homo sapiens
3.5.4.5
3-deazauridine
-
Homo sapiens
3.5.4.5
4-amino-1-(5-hydroxypentyl)pyrimidin-2(1H)-one
-
Homo sapiens
3.5.4.5
4-amino-1-hexyl-5,6-dihydropyrimidin-2(1H)-one
-
Homo sapiens
3.5.4.5
4-hydroxy-1-(beta-D-ribofuranosyl)piperidin-2-one
-
Homo sapiens
3.5.4.5
5,6-Dihydrouridine
-
Escherichia coli
3.5.4.5
5,6-Dihydrouridine
-
Homo sapiens
3.5.4.5
5-(Chloromercuri)cytidine
-
Escherichia coli
3.5.4.5
5-(Chloromercuri)cytidine
-
Homo sapiens
3.5.4.5
5-Bromouridine
-
Homo sapiens
3.5.4.5
5-fluoro-2'-deoxyuridine
-
Homo sapiens
3.5.4.5
5-fluorouridine
-
Homo sapiens
3.5.4.5
5-iodo-2'-deoxyuridine
-
Homo sapiens
3.5.4.5
5-methyluridine
-
Homo sapiens
3.5.4.5
5-{(1E)-3-[(5-carboxypentyl)amino]-3-oxoprop-1-en-1-yl}-5,6-dihydrocytidine
-
Homo sapiens
3.5.4.5
6-azauridine
-
Homo sapiens
3.5.4.5
Ag+
-
Homo sapiens
3.5.4.5
ara-U
-
Homo sapiens
3.5.4.5
CMP
-
Homo sapiens
3.5.4.5
Cu2+
-
Escherichia coli
3.5.4.5
Cu2+
-
Homo sapiens
3.5.4.5
Cu2+
-
Mus musculus
3.5.4.5
dCMP
-
Homo sapiens
3.5.4.5
deoxyadenosine
-
Escherichia coli
3.5.4.5
deoxyadenosine
-
Homo sapiens
3.5.4.5
DTNB
-
Homo sapiens
3.5.4.5
DTNB
-
Mus musculus
3.5.4.5
dTTP
-
Homo sapiens
3.5.4.5
dTTP
-
Mus musculus
3.5.4.5
Hg+
-
Escherichia coli
3.5.4.5
Hg+
-
Homo sapiens
3.5.4.5
Hg+
-
Mus musculus
3.5.4.5
N-ethylmaleimide
weak inhibition
Homo sapiens
3.5.4.5
N-ethylmaleimide
-
Mus musculus
3.5.4.5
p-chloromercuribenzoate
-
Homo sapiens
3.5.4.5
pseudouridine
-
Homo sapiens
3.5.4.5
thymidine
-
Escherichia coli
3.5.4.5
thymidine
-
Homo sapiens
3.5.4.5
thymine riboside
-
Homo sapiens
3.5.4.5
thymine riboside
-
Escherichia coli
3.5.4.5
uridine
-
Escherichia coli
3.5.4.5
uridine
-
Homo sapiens
3.5.4.5
UTP
-
Homo sapiens
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
3.5.4.5
13500
-
4 * 13500, SDS-PAGE
Homo sapiens
3.5.4.5
52000
-
gel filtration
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.5.4.5
cytidine + H2O
Gallus gallus
-
uridine + NH3
-
-
?
3.5.4.5
cytidine + H2O
Mus musculus
-
uridine + NH3
-
-
?
3.5.4.5
cytidine + H2O
Escherichia coli
-
uridine + NH3
-
-
?
3.5.4.5
cytidine + H2O
Homo sapiens
-
uridine + NH3
-
-
?
3.5.4.5
cytidine + H2O
Canis lupus familiaris
-
uridine + NH3
-
-
?
3.5.4.5
cytidine + H2O
Mus musculus BALB/c
-
uridine + NH3
-
-
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
3.5.4.5
-
Gallus gallus
3.5.4.5
-
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.5.4.5
granulocyte
normal and leukemic
Homo sapiens
-
3.5.4.5
liver
-
Canis lupus familiaris
-
3.5.4.5
liver
-
Gallus gallus
-
3.5.4.5
liver
-
Mus musculus
-
3.5.4.5
liver
-
Homo sapiens
-
3.5.4.5
lymphocyte
-
Homo sapiens
-
3.5.4.5
placenta
-
Homo sapiens
-
3.5.4.5
reticulocyte
-
Homo sapiens
-
3.5.4.5
spleen
-
Mus musculus
-
3.5.4.5
spleen
-
Homo sapiens
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
3.5.4.5
64.1
-
-
Homo sapiens
Storage Stability (protein specific)
EC Number
Storage Stability
Organism
3.5.4.5
-20°C, 20% glycerol appears to be necessary to prevent inactivation from occuring after freezing and thawing
Homo sapiens
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.4.5
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine + H2O
-
209661
Homo sapiens
?
-
-
-
?
3.5.4.5
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine + H2O
-
209661
Canis lupus familiaris
?
-
-
-
?
3.5.4.5
1-beta-D-arabinofuranosylcytosine + H2O
-
209661
Mus musculus
?
-
-
-
?
3.5.4.5
1-beta-D-arabinofuranosylcytosine + H2O
-
209661
Escherichia coli
?
-
-
-
?
3.5.4.5
1-beta-D-arabinofuranosylcytosine + H2O
-
209661
Homo sapiens
?
-
-
-
?
3.5.4.5
1-beta-D-arabinofuranosylcytosine + H2O
-
209661
Canis lupus familiaris
?
-
-
-
?
3.5.4.5
2'-deoxycytidine + H2O
-
209661
Mus musculus
2'-deoxyuridine + NH3
-
-
-
?
3.5.4.5
2'-deoxycytidine + H2O
-
209661
Escherichia coli
2'-deoxyuridine + NH3
-
-
-
?
3.5.4.5
2'-deoxycytidine + H2O
-
209661
Homo sapiens
2'-deoxyuridine + NH3
-
-
-
?
3.5.4.5
2'-deoxycytidine + H2O
-
209661
Mus musculus BALB/c
2'-deoxyuridine + NH3
-
-
-
?
3.5.4.5
2'-fluoro-2'-deoxycytidine + H2O
-
209661
Escherichia coli
2'-fluoro-2'-deoxyuridine + NH3
-
-
-
?
3.5.4.5
2'-fluoro-2'-deoxycytidine + H2O
-
209661
Homo sapiens
2'-fluoro-2'-deoxyuridine + NH3
-
-
-
?
3.5.4.5
5'-methyl-2'-deoxycytidine + H2O
-
209661
Mus musculus
5'-methyl-2-deoxyuridine + NH3
-
-
-
?
3.5.4.5
5'-methyl-2'-deoxycytidine + H2O
-
209661
Escherichia coli
5'-methyl-2-deoxyuridine + NH3
-
-
-
?
3.5.4.5
5'-methyl-2'-deoxycytidine + H2O
-
209661
Homo sapiens
5'-methyl-2-deoxyuridine + NH3
-
-
-
?
3.5.4.5
5'-methyl-2'-deoxycytidine + H2O
-
209661
Mus musculus BALB/c
5'-methyl-2-deoxyuridine + NH3
-
-
-
?
3.5.4.5
5-azacytidine + H2O
-
209661
Escherichia coli
5-azauridine + NH3
-
-
-
?
3.5.4.5
5-azacytidine + H2O
-
209661
Homo sapiens
5-azauridine + NH3
-
-
-
?
3.5.4.5
5-azadeoxycytidine + H2O
-
209661
Homo sapiens
5-azadeoxyuridine + NH3
-
-
-
?
3.5.4.5
5-iodo-2'-deoxycytidine
-
209661
Homo sapiens
5-iodo-2'-deoxyuridine + NH3
-
-
-
?
3.5.4.5
5-iododeoxycytidine + H2O
-
209661
Mus musculus
5-iododeoxyuridine + NH3
-
-
-
?
3.5.4.5
5-iododeoxycytidine + H2O
-
209661
Homo sapiens
5-iododeoxyuridine + NH3
-
-
-
?
3.5.4.5
5-methylcytidine + H2O
-
209661
Escherichia coli
5-methyluridine + NH3
-
-
-
?
3.5.4.5
5-methylcytidine + H2O
-
209661
Homo sapiens
5-methyluridine + NH3
-
-
-
?
3.5.4.5
cytidine + H2O
-
209661
Gallus gallus
uridine + NH3
-
-
-
?
3.5.4.5
cytidine + H2O
-
209661
Mus musculus
uridine + NH3
-
-
-
?
3.5.4.5
cytidine + H2O
-
209661
Escherichia coli
uridine + NH3
-
-
-
?
3.5.4.5
cytidine + H2O
-
209661
Homo sapiens
uridine + NH3
-
-
-
?
3.5.4.5
cytidine + H2O
-
209661
Canis lupus familiaris
uridine + NH3
-
-
-
?
3.5.4.5
cytidine + H2O
-
209661
Mus musculus BALB/c
uridine + NH3
-
-
-
?
3.5.4.5
cytosine arabinoside + H2O
-
209661
Mus musculus
uridine arabinoside + NH3
-
-
-
?
3.5.4.5
cytosine arabinoside + H2O
-
209661
Escherichia coli
uridine arabinoside + NH3
-
-
-
?
3.5.4.5
cytosine arabinoside + H2O
-
209661
Homo sapiens
uridine arabinoside + NH3
-
-
-
?
3.5.4.5
cytosine arabinoside + H2O
-
209661
Mus musculus BALB/c
uridine arabinoside + NH3
-
-
-
?
3.5.4.5
deoxycytidine + H2O
-
209661
Mus musculus
deoxyuridine + NH3
-
-
-
?
3.5.4.5
deoxycytidine + H2O
-
209661
Escherichia coli
deoxyuridine + NH3
-
-
-
?
3.5.4.5
deoxycytidine + H2O
-
209661
Homo sapiens
deoxyuridine + NH3
-
-
-
?
3.5.4.5
deoxycytidine + H2O
-
209661
Canis lupus familiaris
deoxyuridine + NH3
-
-
-
?
3.5.4.5
deoxycytidine + H2O
-
209661
Mus musculus BALB/c
deoxyuridine + NH3
-
-
-
?
3.5.4.5
additional information
-
209661
Escherichia coli
?
-
-
-
-
3.5.4.5
additional information
3-methylcytidine, cytosine and cyclocytidine are no substrates
209661
Homo sapiens
?
-
-
-
-
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
3.5.4.5
tetramer
-
Gallus gallus
3.5.4.5
tetramer
4 * 13500, SDS-PAGE
Homo sapiens
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
3.5.4.5
7.5
-
-
Homo sapiens
pH Range (protein specific)
EC Number
pH Minimum
pH Maximum
Commentary
Organism
3.5.4.5
3.5
10.5
deoxycytidine as substrate, beyond these values irreversible inactivation occurs
Homo sapiens
pH Stability (protein specific)
EC Number
pH Stability
pH Stability Maximum
Commentary
Organism
3.5.4.5
3.5
10.5
deoxycytidine as substrate, beyond these extremes rapid inactivation
Homo sapiens