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Literature summary extracted from
- Characteristics of cytidine aminohydrolase activity in Trypanosoma cruzi and Crithidia fasciculata (1984), J. Protozool., 31, 298-300.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.4.5 | 5-Bromouridine | - |
Crithidia fasciculata |  |
| 3.5.4.5 | cytidine | - |
Crithidia fasciculata | |
| 3.5.4.5 | cytidine | - |
Trypanosoma cruzi | |
| 3.5.4.5 | Orotidine | - |
Crithidia fasciculata | |
| 3.5.4.5 | thymidine | - |
Crithidia fasciculata | |
| 3.5.4.5 | uridine | - |
Crithidia fasciculata | |
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 3.5.4.5 | unstable in air, even in the frozen state, stabilization achieved under anaerobic conditions | Crithidia fasciculata |
| 3.5.4.5 | unstable in air, even in the frozen state, stabilization achieved under anaerobic conditions | Trypanosoma cruzi |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.4.5 | p-mercuribenzoate | - |
Crithidia fasciculata | |
| 3.5.4.5 | p-mercuribenzoate | - |
Trypanosoma cruzi | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.5.4.5 | 0.09 | 0.1 | deoxycytidine | - |
Crithidia fasciculata | |
| 3.5.4.5 | 1.8 | 1.9 | cytidine | radioactive labeled substrate | Trypanosoma cruzi | |
| 3.5.4.5 | 1.8 | 1.9 | deoxycytidine | radioactive labeled substrate | Trypanosoma cruzi | |
| 3.5.4.5 | 2.8 | 3 | cytidine | - |
Crithidia fasciculata | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.5.4.5 | 45000 | - |
gel filtration | Crithidia fasciculata |
| 3.5.4.5 | 90000 | - |
gel filtration | Trypanosoma cruzi |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.4.5 | cytidine + H2O | Crithidia fasciculata | - |
uridine + NH3 | - |
? | |
| 3.5.4.5 | cytidine + H2O | Trypanosoma cruzi | - |
uridine + NH3 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.4.5 | Crithidia fasciculata | - |
mosquito parasite | - |
| 3.5.4.5 | Trypanosoma cruzi | - |
human pathogen, Culbertson strain, epimastigotes, ATCC 30013 | - |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 3.5.4.5 | -20°C, enzyme lost about 50% activity after 24 h, essentially all activity lost after 48 h | Crithidia fasciculata |
| 3.5.4.5 | -20°C, enzyme lost about 50% activity after 24 h, no activity remains after 24 h | Trypanosoma cruzi |
| 3.5.4.5 | 4°C, enzyme lost about 50% activity after 24 h, essentially all activity lost after 48 h | Crithidia fasciculata |
| 3.5.4.5 | 4°C, enzyme lost about 50% activity after 24 h, no activity remains after 24 h | Trypanosoma cruzi |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.4.5 | cytidine + H2O | - |
Crithidia fasciculata | uridine + NH3 | - |
? | |
| 3.5.4.5 | cytidine + H2O | - |
Trypanosoma cruzi | uridine + NH3 | - |
? | |
| 3.5.4.5 | deoxycytidine + H2O | - |
Crithidia fasciculata | deoxyuridine + NH3 | - |
? | |
| 3.5.4.5 | deoxycytidine + H2O | - |
Trypanosoma cruzi | deoxyuridine + NH3 | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.5.4.5 | 6.5 | 8.5 | - |
Crithidia fasciculata |
| 3.5.4.5 | 6.5 | 8.5 | - |
Trypanosoma cruzi |
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