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Literature summary extracted from

  • Lupidi, G.; Marmocchi, F.; Cristalli, G.
    Inhibition studies on membrane adenosine deaminase from human placenta (1998), Biochem. Mol. Biol. Int., 46, 1071-1080.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.5.4.4 medicine therapy for adenosine-deficient patients with combined immunodeficiency Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.4 aza adenosine analogues
-
 Homo sapiens
3.5.4.4 deaza adenosine analogues
-
 Homo sapiens
3.5.4.4 Deoxycoformycin
-
 Homo sapiens
3.5.4.4 erythro-9-(2-hydroxy-3-nonyl)adenine
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.4 0.033
-
 adenosine
-
 Homo sapiens
3.5.4.4 0.052
-
 2'-deoxyadenosine
-
 Homo sapiens
3.5.4.4 0.081
-
 6-methoxypurinriboside
-
 Homo sapiens
3.5.4.4 0.277
-
 6-chloropurinriboside
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.4 Homo sapiens
-
 normal B-cells and T-cell lines MOLT-4
-
3.5.4.4 Homo sapiens
-
 RPMI-8402
-
3.5.4.4 Homo sapiens
-
 CCRF-CEM
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.4 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.4 2'-deoxyadenosine + H2O
-
 Homo sapiens 2'-deoxyinosine + NH3
-
 ?
3.5.4.4 6-chloropurine riboside + H2O
-
 Homo sapiens inosine + Cl-
-
 ?
3.5.4.4 6-chloropurinriboside + H2O
-
 Homo sapiens inosine + Cl-
-
 ?
3.5.4.4 6-methoxypurinriboside
-
 Homo sapiens ?
-
 ?
3.5.4.4 adenosine + H2O
-
 Homo sapiens inosine + NH3
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.4 7
-
-
 Homo sapiens